4ktx
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ktx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ktx RCSB], [http://www.ebi.ac.uk/pdbsum/4ktx PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ktx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ktx RCSB], [http://www.ebi.ac.uk/pdbsum/4ktx PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BXA1_CLOBH BXA1_CLOBH]] Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bontoxilysin]] | [[Category: Bontoxilysin]] | ||
| - | [[Category: Dive, V | + | [[Category: Dive, V]] |
| - | [[Category: Guitot, K | + | [[Category: Guitot, K]] |
| - | [[Category: Stura, E A | + | [[Category: Stura, E A]] |
| - | [[Category: Vera, L | + | [[Category: Vera, L]] |
[[Category: Clostridial neurotoxin zinc protease]] | [[Category: Clostridial neurotoxin zinc protease]] | ||
[[Category: Covalent inhibition]] | [[Category: Covalent inhibition]] | ||
Revision as of 19:13, 25 December 2014
Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134S mutant with covalent inhibitor that modifies Cys-165 causing disorder in 167-174 stretch
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