4rhw
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rhw RCSB], [http://www.ebi.ac.uk/pdbsum/4rhw PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rhw RCSB], [http://www.ebi.ac.uk/pdbsum/4rhw PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/APAF_HUMAN APAF_HUMAN]] Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.<ref>PMID:10393175</ref> <ref>PMID:12804598</ref> [[http://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Caspase-9]] | [[Category: Caspase-9]] | ||
| - | [[Category: Hu, Q | + | [[Category: Hu, Q]] |
| - | [[Category: Shi, Y | + | [[Category: Shi, Y]] |
| - | [[Category: Wu, D | + | [[Category: Wu, D]] |
| - | [[Category: Yan, C | + | [[Category: Yan, C]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Death domain superfamily]] | [[Category: Death domain superfamily]] | ||
Revision as of 15:45, 25 December 2014
Crystal structure of Apaf-1 CARD and caspase-9 CARD complex
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Categories: Caspase-9 | Hu, Q | Shi, Y | Wu, D | Yan, C | Apoptosis | Death domain superfamily
