This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2kwh
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kwh RCSB], [http://www.ebi.ac.uk/pdbsum/2kwh PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kwh RCSB], [http://www.ebi.ac.uk/pdbsum/2kwh PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RBP1_HUMAN RBP1_HUMAN]] Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.<ref>PMID:7673236</ref> <ref>PMID:12775724</ref> <ref>PMID:11437348</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 30: | Line 32: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Camonis, J | + | [[Category: Camonis, J]] |
| - | [[Category: Campbell, L J | + | [[Category: Campbell, L J]] |
| - | [[Category: Fenwick, R B | + | [[Category: Fenwick, R B]] |
| - | [[Category: Mott, H R | + | [[Category: Mott, H R]] |
| - | [[Category: Nietlispach, D | + | [[Category: Nietlispach, D]] |
| - | [[Category: Owen, D | + | [[Category: Owen, D]] |
| - | [[Category: Prasannan, S | + | [[Category: Prasannan, S]] |
| - | [[Category: Rajasekar, K | + | [[Category: Rajasekar, K]] |
[[Category: Gtpase activation]] | [[Category: Gtpase activation]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 04:14, 25 December 2014
Ral binding domain of RLIP76 (RalBP1)
| |||||||||||
