2l0y
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l0y RCSB], [http://www.ebi.ac.uk/pdbsum/2l0y PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l0y RCSB], [http://www.ebi.ac.uk/pdbsum/2l0y PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MIA40_HUMAN MIA40_HUMAN]] Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system.<ref>PMID:16185709</ref> <ref>PMID:23186364</ref> <ref>PMID:19182799</ref> <ref>PMID:21059946</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 22: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bertini, I | + | [[Category: Bertini, I]] |
| - | [[Category: Ciofi-Baffoni, S | + | [[Category: Ciofi-Baffoni, S]] |
| - | [[Category: Gallo, A | + | [[Category: Gallo, A]] |
[[Category: Macromolecular complex]] | [[Category: Macromolecular complex]] | ||
[[Category: Mitochondrial import]] | [[Category: Mitochondrial import]] | ||
[[Category: Oxidative protein folding]] | [[Category: Oxidative protein folding]] | ||
[[Category: Protein transport-metal transport complex]] | [[Category: Protein transport-metal transport complex]] | ||
Revision as of 14:29, 24 December 2014
Complex hMia40-hCox17
| |||||||||||
