2l0r
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l0r RCSB], [http://www.ebi.ac.uk/pdbsum/2l0r PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l0r RCSB], [http://www.ebi.ac.uk/pdbsum/2l0r PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LEF_BACAN LEF_BACAN]] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. LF is the lethal factor that, when associated with PA, causes death. LF is not toxic by itself. It is a protease that cleaves the N-terminal of most dual specificity mitogen-activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N-terminal proline-rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein-protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LeTx intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates.<ref>PMID:9563949</ref> <ref>PMID:9703991</ref> <ref>PMID:10475971</ref> <ref>PMID:11104681</ref> <ref>PMID:10338520</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Anthrax Lethal Factor|Anthrax Lethal Factor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Anthrax lethal factor endopeptidase]] | [[Category: Anthrax lethal factor endopeptidase]] | ||
[[Category: Bacillus anthracis]] | [[Category: Bacillus anthracis]] | ||
| - | [[Category: Bentrop, D A | + | [[Category: Bentrop, D A]] |
| - | [[Category: Chasapis, C T | + | [[Category: Chasapis, C T]] |
| - | [[Category: Dalkas, G A | + | [[Category: Dalkas, G A]] |
| - | [[Category: Gkazonis, P V | + | [[Category: Gkazonis, P V]] |
| - | [[Category: Spyroulias, G A | + | [[Category: Spyroulias, G A]] |
[[Category: Anthrax lethal factor]] | [[Category: Anthrax lethal factor]] | ||
| - | [[Category: Bacillus anthracis]] | ||
[[Category: Catalytic domain]] | [[Category: Catalytic domain]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 01:47, 25 December 2014
Conformational Dynamics of the Anthrax Lethal Factor Catalytic Center
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