2ns3
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ns3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ns3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ns3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ns3 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ns3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ns3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ns3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ns3 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CXA1_CONBU CXA1_CONBU]] Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This peptide potently blocks numerous mammalian nAChR subtypes (alpha-6 or -3/beta-2 or -3 > alpha-6 or-3/beta-4 > alpha-3/beta-2 > alpha-3/beta-4 > alpha-4/beta-4 = alpha-2/beta-4 > alpha-7 > alpha-2/beta-2 >> alpha-4/beta-2). Recovery from toxin block is markedly slower for beta-4 versus beta-2 subunit-containing nAChRs. Thus, it represents a novel probe for distinguishing between beta-2 and beta-4-containing nAChRs. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Adams, D J | + | [[Category: Adams, D J]] |
| - | [[Category: Alewood, P F | + | [[Category: Alewood, P F]] |
| - | [[Category: Brandstaetter, H | + | [[Category: Brandstaetter, H]] |
| - | [[Category: Clark, R J | + | [[Category: Clark, R J]] |
| - | [[Category: Craik, D J | + | [[Category: Craik, D J]] |
| - | [[Category: Daly, N L | + | [[Category: Daly, N L]] |
| - | [[Category: Jin, A H | + | [[Category: Jin, A H]] |
| - | [[Category: Nevin, S T | + | [[Category: Nevin, S T]] |
| - | [[Category: Tan, C C | + | [[Category: Tan, C C]] |
[[Category: Ribbon disulfide connectivity]] | [[Category: Ribbon disulfide connectivity]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 17:13, 24 December 2014
Solution structure of ribbon BuIA
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