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4wf2
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wf2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wf2 RCSB], [http://www.ebi.ac.uk/pdbsum/4wf2 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wf2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wf2 RCSB], [http://www.ebi.ac.uk/pdbsum/4wf2 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BIRA_ECOLI BIRA_ECOLI]] Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.<ref>PMID:6129246</ref> <ref>PMID:2667763</ref> <ref>PMID:8003500</ref> <ref>PMID:12527300</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Beckett, D | + | [[Category: Beckett, D]] |
| - | [[Category: Eginton, C | + | [[Category: Eginton, C]] |
| - | [[Category: Wade, H | + | [[Category: Wade, H]] |
[[Category: Biotin protein ligase]] | [[Category: Biotin protein ligase]] | ||
[[Category: Biotin repressor]] | [[Category: Biotin repressor]] | ||
[[Category: Complex with biotinol-5'-amp]] | [[Category: Complex with biotinol-5'-amp]] | ||
[[Category: G142a mutant]] | [[Category: G142a mutant]] | ||
Revision as of 12:45, 25 December 2014
Structure of E. coli BirA G142A bound to biotinol-5'-AMP
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