2xp3
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xp3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xp3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xp3 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xp3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xp3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xp3 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Peptidylprolyl isomerase]] | [[Category: Peptidylprolyl isomerase]] | ||
| - | [[Category: Baker, L | + | [[Category: Baker, L]] |
| - | [[Category: Bryant, C J | + | [[Category: Bryant, C J]] |
| - | [[Category: Davis, B E | + | [[Category: Davis, B E]] |
| - | [[Category: Dokurno, P | + | [[Category: Dokurno, P]] |
| - | [[Category: Fromont, C | + | [[Category: Fromont, C]] |
| - | [[Category: Matossova, N | + | [[Category: Matossova, N]] |
| - | [[Category: Moore, J D | + | [[Category: Moore, J D]] |
| - | [[Category: Murray, J B | + | [[Category: Murray, J B]] |
| - | [[Category: Northfield, C J | + | [[Category: Northfield, C J]] |
| - | [[Category: Nunns, C | + | [[Category: Nunns, C]] |
| - | [[Category: Oldfield, V | + | [[Category: Oldfield, V]] |
| - | [[Category: Potter, A | + | [[Category: Potter, A]] |
| - | [[Category: Ray, S | + | [[Category: Ray, S]] |
| - | [[Category: Richardson, C M | + | [[Category: Richardson, C M]] |
| - | [[Category: Robinson, D | + | [[Category: Robinson, D]] |
| - | [[Category: Scrace, S F | + | [[Category: Scrace, S F]] |
| - | [[Category: Surgenor, A E | + | [[Category: Surgenor, A E]] |
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Isomerase]] | [[Category: Isomerase]] | ||
[[Category: Oncogenic transformation]] | [[Category: Oncogenic transformation]] | ||
[[Category: Proline directed kinase]] | [[Category: Proline directed kinase]] | ||
Revision as of 04:18, 25 December 2014
DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION
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Categories: Homo sapiens | Peptidylprolyl isomerase | Baker, L | Bryant, C J | Davis, B E | Dokurno, P | Fromont, C | Matossova, N | Moore, J D | Murray, J B | Northfield, C J | Nunns, C | Oldfield, V | Potter, A | Ray, S | Richardson, C M | Robinson, D | Scrace, S F | Surgenor, A E | Cell cycle | Isomerase | Oncogenic transformation | Proline directed kinase
