2xzt

(Difference between revisions)

Revision as of 14:50, 25 December 2014

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 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xzt RCSB], [http://www.ebi.ac.uk/pdbsum/2xzt PDBsum]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
 ==See Also==
 *[[Caspase|Caspase]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
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 [[Category: Homo sapiens]]
 [[Category: Unidentified]]
-[[Category: Barandun, J.]]
+[[Category: Barandun, J]]
-[[Category: Grutter, M G.]]
+[[Category: Grutter, M G]]
-[[Category: Mittl, P.]]
+[[Category: Mittl, P]]
-[[Category: Schroeder, T.]]
+[[Category: Schroeder, T]]
 [[Category: Ankyrin repeat protein]]
 [[Category: Apoptosis]]