4o64
From Proteopedia
(Difference between revisions)
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<StructureSection load='4o64' size='340' side='right' caption='[[4o64]], [[Resolution|resolution]] 2.13Å' scene=''> | <StructureSection load='4o64' size='340' side='right' caption='[[4o64]], [[Resolution|resolution]] 2.13Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4o64]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O64 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O64 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4o64]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O64 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O64 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KDM2B, CXXC2, FBL10, FBXL10, JHDM1B, PCCX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o64 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o64 RCSB], [http://www.ebi.ac.uk/pdbsum/4o64 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o64 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o64 RCSB], [http://www.ebi.ac.uk/pdbsum/4o64 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KDM2B_HUMAN KDM2B_HUMAN]] Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<ref>PMID:16362057</ref> <ref>PMID:17994099</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Arrowsmith, C H | + | [[Category: Human]] |
| - | [[Category: Bountra, C | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Edwards, A M | + | [[Category: Bountra, C]] |
| - | [[Category: Liu, K | + | [[Category: Edwards, A M]] |
| - | [[Category: Min, J | + | [[Category: Liu, K]] |
| - | [[Category: | + | [[Category: Min, J]] |
| - | [[Category: Tempel, W | + | [[Category: Structural genomic]] |
| - | [[Category: Walker, J R | + | [[Category: Tempel, W]] |
| - | [[Category: Xu, C | + | [[Category: Walker, J R]] |
| + | [[Category: Xu, C]] | ||
[[Category: Cxxc zinc finger]] | [[Category: Cxxc zinc finger]] | ||
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
[[Category: Ring zinc finger]] | [[Category: Ring zinc finger]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics consortium]] | ||
Revision as of 01:12, 25 December 2014
Zinc fingers of KDM2B
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Categories: Human | Arrowsmith, C H | Bountra, C | Edwards, A M | Liu, K | Min, J | Structural genomic | Tempel, W | Walker, J R | Xu, C | Cxxc zinc finger | Metal binding protein | Ring zinc finger | Sgc
