4qzv
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qzv RCSB], [http://www.ebi.ac.uk/pdbsum/4qzv PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qzv RCSB], [http://www.ebi.ac.uk/pdbsum/4qzv PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DPP4_HUMAN DPP4_HUMAN]] Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.<ref>PMID:10951221</ref> <ref>PMID:17549790</ref> <ref>PMID:10570924</ref> <ref>PMID:10900005</ref> <ref>PMID:11772392</ref> <ref>PMID:14691230</ref> <ref>PMID:16651416</ref> <ref>PMID:17287217</ref> <ref>PMID:18708048</ref> [[http://www.uniprot.org/uniprot/SPIKE_BCHK4 SPIKE_BCHK4]] S1 region attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Dipeptidyl-peptidase IV]] | [[Category: Dipeptidyl-peptidase IV]] | ||
| - | [[Category: Gao, F G | + | [[Category: Gao, F G]] |
| - | [[Category: Lu, G W | + | [[Category: Lu, G W]] |
| - | [[Category: Qi, J X | + | [[Category: Qi, J X]] |
| - | [[Category: Wang, Q H | + | [[Category: Wang, Q H]] |
[[Category: 8-bladed beta-propeller domain]] | [[Category: 8-bladed beta-propeller domain]] | ||
[[Category: Alpha/beta hydrolase domain]] | [[Category: Alpha/beta hydrolase domain]] | ||
Revision as of 12:55, 25 December 2014
Bat-derived coronavirus HKU4 uses MERS-CoV receptor human CD26 for cell entry
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