2z8o
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z8o RCSB], [http://www.ebi.ac.uk/pdbsum/2z8o PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z8o RCSB], [http://www.ebi.ac.uk/pdbsum/2z8o PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VRP3_SALTY VRP3_SALTY]] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized proinflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.<ref>PMID:17303758</ref> <ref>PMID:18060821</ref> <ref>PMID:18084305</ref> <ref>PMID:18284579</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]] | [[Category: Salmonella enterica subsp. enterica serovar typhimurium]] | ||
| - | [[Category: Chai, J | + | [[Category: Chai, J]] |
| - | [[Category: Chen, L | + | [[Category: Chen, L]] |
| - | [[Category: Gu, L | + | [[Category: Gu, L]] |
| - | [[Category: Huang, N | + | [[Category: Huang, N]] |
| - | [[Category: Wang, H | + | [[Category: Wang, H]] |
| - | [[Category: Zhou, J M | + | [[Category: Zhou, J M]] |
[[Category: Distorted beta-strand sheet]] | [[Category: Distorted beta-strand sheet]] | ||
[[Category: Lyase]] | [[Category: Lyase]] | ||
[[Category: Short three-helix bundle]] | [[Category: Short three-helix bundle]] | ||
Revision as of 12:13, 25 December 2014
Structural basis for the catalytic mechanism of phosphothreonine lyase
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