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2dcw
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dcw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dcw RCSB], [http://www.ebi.ac.uk/pdbsum/2dcw PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dcw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dcw RCSB], [http://www.ebi.ac.uk/pdbsum/2dcw PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TACB2_TACTR TACB2_TACTR]] Exhibits stronger antimicrobial activity against the Gram-positive bacteria (S.aureus (IC(50) is 7.4 ug/ml)) and fungi (C.albicans (IC(50) is 3.0 ug/ml) and P.pastoris (IC(50) is 0.1 ug/ml)) than Gram-negative bacteria (E.coli no inhibition at 100 ug/ml). Binds to chitin (4.3 uM are required to obtain 50% of binding). Does not cause hemolysis on sheep erythrocytes. Has no blocking activity on the P-type calcium channel. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Tachypleus tridentatus]] | [[Category: Tachypleus tridentatus]] | ||
| - | [[Category: Fujitani, N | + | [[Category: Fujitani, N]] |
| - | [[Category: Kawano, K | + | [[Category: Kawano, K]] |
[[Category: Antimicrobial]] | [[Category: Antimicrobial]] | ||
[[Category: Antimicrobial protein]] | [[Category: Antimicrobial protein]] | ||
[[Category: Cystine-knot]] | [[Category: Cystine-knot]] | ||
Revision as of 16:55, 24 December 2014
The solution structure of horseshoe crab antimicrobial peptide tachystatin b with the inhibitory cystine-knot motif
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