1oeu
From Proteopedia
(Difference between revisions)
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<StructureSection load='1oeu' size='340' side='right' caption='[[1oeu]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='1oeu' size='340' side='right' caption='[[1oeu]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1oeu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEU FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1oeu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEU FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oeu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oeu RCSB], [http://www.ebi.ac.uk/pdbsum/1oeu PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oeu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oeu RCSB], [http://www.ebi.ac.uk/pdbsum/1oeu PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Protein-tyrosine-phosphatase]] | [[Category: Protein-tyrosine-phosphatase]] | ||
| - | [[Category: Carr, R | + | [[Category: Carr, R]] |
| - | [[Category: Congreve, M | + | [[Category: Congreve, M]] |
| - | [[Category: Jhoti, H | + | [[Category: Jhoti, H]] |
| - | [[Category: Montfort, R L.M Van | + | [[Category: Montfort, R L.M Van]] |
| - | [[Category: Tisi, D | + | [[Category: Tisi, D]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Oxidative regulation]] | [[Category: Oxidative regulation]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
[[Category: Protein tyrosine phosphatase]] | [[Category: Protein tyrosine phosphatase]] | ||
Revision as of 18:12, 24 December 2014
Oxidation state of protein tyrosine phosphatase 1B
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