1k8v
From Proteopedia
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|PDB= 1k8v |SIZE=350|CAPTION= <scene name='initialview01'>1k8v</scene> | |PDB= 1k8v |SIZE=350|CAPTION= <scene name='initialview01'>1k8v</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | + | |LIGAND= <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8v OCA], [http://www.ebi.ac.uk/pdbsum/1k8v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k8v RCSB]</span> | ||
}} | }} | ||
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[[Category: Kotovych, G.]] | [[Category: Kotovych, G.]] | ||
[[Category: Miskolzie, M.]] | [[Category: Miskolzie, M.]] | ||
| - | [[Category: NH2]] | ||
[[Category: moniezia expansa]] | [[Category: moniezia expansa]] | ||
[[Category: neuropeptide f]] | [[Category: neuropeptide f]] | ||
[[Category: npf]] | [[Category: npf]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:45:02 2008'' |
Revision as of 18:45, 30 March 2008
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The NMR-derived Conformation of Neuropeptide F from Moniezia expansa
Overview
The solution structure of neuropeptide F (NPF), from the flatworm (platyhelminthes) Moniezia expansa, has been determined by (1)H NMR spectroscopy at 800 MHz in 60%/40% CD(3)OH/H(2)O. NPF is the most abundant neuropeptide in platyhelminthes. The secondary structure of NPF contains an alpha helix from residues Lys(14) to Ile(31), while the N terminus, consisting of residues Pro(-2) to Asn(13), and the C-terminus, consisting of residues Gly(32) to Phe(36), are in a random conformation. The structure was calculated by a simulated annealing protocol, and the conformational data are compared to the porcine neuropeptide Y (NPY), a peptide hormone and neurotransmitter. The exact function of NPF is unknown, but structural similarity with porcine NPY indicates that its mode of action is similar. These structural data can serve as a starting point in the design of new antiparasitic drugs.
About this Structure
1K8V is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
The NMR-derived conformation of neuropeptide F from Moniezia expansa., Miskolzie M, Kotovych G, J Biomol Struct Dyn. 2002 Jun;19(6):991-8. PMID:12023801
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