1k9k
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1k9k |SIZE=350|CAPTION= <scene name='initialview01'>1k9k</scene>, resolution 1.76Å | |PDB= 1k9k |SIZE=350|CAPTION= <scene name='initialview01'>1k9k</scene>, resolution 1.76Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= S100A6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= S100A6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1k8u|1K8U]], [[1k96|1K96]], [[1k9p|1K9P]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k9k OCA], [http://www.ebi.ac.uk/pdbsum/1k9k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k9k RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Dominguez, R.]] | [[Category: Dominguez, R.]] | ||
[[Category: Otterbein, L R.]] | [[Category: Otterbein, L R.]] | ||
| - | [[Category: BME]] | ||
| - | [[Category: CA]] | ||
[[Category: cacy]] | [[Category: cacy]] | ||
[[Category: calcium bound]] | [[Category: calcium bound]] | ||
| Line 32: | Line 33: | ||
[[Category: s100a6]] | [[Category: s100a6]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:45:20 2008'' |
Revision as of 18:45, 30 March 2008
| |||||||
| , resolution 1.76Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | S100A6 (Homo sapiens) | ||||||
| Related: | 1K8U, 1K96, 1K9P
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF CALCIUM BOUND HUMAN S100A6
Overview
S100A6 is a member of the S100 family of Ca(2+) binding proteins, which have come to play an important role in the diagnosis of cancer due to their overexpression in various tumor cells. We have determined the crystal structures of human S100A6 in the Ca(2+)-free and Ca(2+)-bound states to resolutions of 1.15 A and 1.44 A, respectively. Ca(2+) binding is responsible for a dramatic change in the global shape and charge distribution of the S100A6 dimer, leading to the exposure of two symmetrically positioned target binding sites. The results are consistent with S100A6, and most likely other S100 proteins, functioning as Ca(2+) sensors in a way analogous to the prototypical sensors calmodulin and troponin C. The structures have important implications for our understanding of target binding and cooperativity of Ca(2+) binding in the S100 family.
About this Structure
1K9K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution., Otterbein LR, Kordowska J, Witte-Hoffmann C, Wang CL, Dominguez R, Structure. 2002 Apr;10(4):557-67. PMID:11937060
Page seeded by OCA on Sun Mar 30 21:45:20 2008
