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4p9l
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p9l RCSB], [http://www.ebi.ac.uk/pdbsum/4p9l PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p9l RCSB], [http://www.ebi.ac.uk/pdbsum/4p9l PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RYR2_MOUSE RYR2_MOUSE]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10473538</ref> <ref>PMID:9628868</ref> <ref>PMID:21098440</ref> <ref>PMID:20431056</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Lau, K | + | [[Category: Lau, K]] |
| - | [[Category: Petegem, F Van | + | [[Category: Petegem, F Van]] |
[[Category: Calcium]] | [[Category: Calcium]] | ||
[[Category: Ion channel]] | [[Category: Ion channel]] | ||
Revision as of 12:16, 25 December 2014
Crystal Structure of mouse Ryanodine Receptor 2 SPRY2 Domain (1080-1253) disease mutant A1107M
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