4v2v
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v2v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v2v RCSB], [http://www.ebi.ac.uk/pdbsum/4v2v PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v2v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v2v RCSB], [http://www.ebi.ac.uk/pdbsum/4v2v PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> [[http://www.uniprot.org/uniprot/H31T_HUMAN H31T_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Chowdhury, R | + | [[Category: Chowdhury, R]] |
| - | [[Category: Madden, S K | + | [[Category: Madden, S K]] |
| - | [[Category: Schofield, C J | + | [[Category: Schofield, C J]] |
[[Category: 2-oxoglutarate]] | [[Category: 2-oxoglutarate]] | ||
[[Category: Chromatin regulator]] | [[Category: Chromatin regulator]] | ||
Revision as of 06:49, 25 December 2014
JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (25-29) ARK(me3)SA
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Categories: Chowdhury, R | Madden, S K | Schofield, C J | 2-oxoglutarate | Chromatin regulator | Dioxygenase | Double-stranded beta helix | Dsbh | Epigenetic and transcription regulation | Facial triad | Hydroxylation | Iron | Jmjc domain | Metal binding protein | Non-heme | Oxidoreductase | Oxygenase
