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4wrh
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wrh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wrh RCSB], [http://www.ebi.ac.uk/pdbsum/4wrh PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wrh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wrh RCSB], [http://www.ebi.ac.uk/pdbsum/4wrh PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Flanagan, J U | + | [[Category: Flanagan, J U]] |
| - | [[Category: Squire, C J | + | [[Category: Squire, C J]] |
| - | [[Category: Yosaatmadja, Y | + | [[Category: Yosaatmadja, Y]] |
[[Category: Complex]] | [[Category: Complex]] | ||
[[Category: Inhibitor]] | [[Category: Inhibitor]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||
Revision as of 13:49, 25 December 2014
AKR1C3 complexed with breakdown product of N-(tert-butyl)-2-(2-chloro-4-(((3-mercapto-5-methyl-4H-1,2,4-triazol-4-yl)amino)methyl)-6-methoxyphenoxy)acetamide
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