2kni
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kni OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kni RCSB], [http://www.ebi.ac.uk/pdbsum/2kni PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kni OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kni RCSB], [http://www.ebi.ac.uk/pdbsum/2kni PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TXP1_PSACA TXP1_PSACA]] Potently and selectively blocks the acid-sensing ion channel ASIC1a/ACCN2. The blockade is rapid and reversible. Psalmotoxin 1 loses its capacity to block ASIC1a/ACCN2 as soon as this subunit is associated with another member of the family (ASIC2a/ACCN1 or ASIC3/ACCN3). The toxin can distinguish between the two ASIC1/ACCN2 splice variants ASIC1a/ACCN2 and ASIC1b/ACCN2.<ref>PMID:10829030</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Psalmopoeus cambridgei]] | [[Category: Psalmopoeus cambridgei]] | ||
| - | [[Category: King, G F | + | [[Category: King, G F]] |
| - | [[Category: Mobli, M | + | [[Category: Mobli, M]] |
| - | [[Category: Saez, N J | + | [[Category: Saez, N J]] |
[[Category: Acid sensing ion channel 1a inhibitor]] | [[Category: Acid sensing ion channel 1a inhibitor]] | ||
[[Category: Asic1a inhibitor]] | [[Category: Asic1a inhibitor]] | ||
Revision as of 19:51, 25 December 2014
High-resolution solution structure of the ASIC1a blocker PcTX1
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