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2hhl
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hhl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hhl RCSB], [http://www.ebi.ac.uk/pdbsum/2hhl PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2hhl TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hhl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hhl RCSB], [http://www.ebi.ac.uk/pdbsum/2hhl PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2hhl TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CTDSL_HUMAN CTDSL_HUMAN]] Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.<ref>PMID:15681389</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 01:55, 25 December 2014
Crystal structure of the human small CTD phosphatase 3 isoform 1
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Categories: Homo sapiens | Adams, J M | Almo, S C | Atwell, S | Bain, K T | Boice, A | Burley, S K | Dickey, M | Emtage, S | Gheyi, T | Groshong, C | Malashkevich, V N | Structural genomic | Ozyurt, S | Powell, A | Ramagopal, U | Reyes, C | Rooney, I | Rutter, M E | Sauder, J M | Schwinn, K D | Thompson, D A | Toro, R | Wasserman, S R | Ctd phosphatase | Hydrolase | Keggins anion | NYSGXRC, New York SGX Research Center for Structural Genomics | PSI, Protein structure initiative
