1kix
From Proteopedia
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|PDB= 1kix |SIZE=350|CAPTION= <scene name='initialview01'>1kix</scene>, resolution 2.70Å | |PDB= 1kix |SIZE=350|CAPTION= <scene name='initialview01'>1kix</scene>, resolution 2.70Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= MAC-56A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=200597 Sterkiella nova]) | |GENE= MAC-56A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=200597 Sterkiella nova]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1otc|1otc]], [[1jb7|1jb7]], [[1k8g|1k8g]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kix OCA], [http://www.ebi.ac.uk/pdbsum/1kix PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kix RCSB]</span> | ||
}} | }} | ||
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[[Category: Ruggles, J A.]] | [[Category: Ruggles, J A.]] | ||
[[Category: Schultz, S C.]] | [[Category: Schultz, S C.]] | ||
| - | [[Category: SO4]] | ||
[[Category: dna-protein interaction]] | [[Category: dna-protein interaction]] | ||
[[Category: single stranded dna]] | [[Category: single stranded dna]] | ||
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[[Category: telomere binding protein]] | [[Category: telomere binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:49:13 2008'' |
Revision as of 18:49, 30 March 2008
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| , resolution 2.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Gene: | MAC-56A (Sterkiella nova) | ||||||
| Related: | 1otc, 1jb7, 1k8g
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Dimeric Structure of the O. nova Telomere End Binding Protein Alpha Subunit with Bound ssDNA
Overview
Telomeres are the specialized protein--DNA complexes that cap and protect the ends of linear eukaryotic chromosomes. The extreme 3' end of the telomeric DNA in Oxytricha nova is bound by a two-subunit sequence-specific and 3' end-specific protein called the telomere end-binding protein (OnTEBP). Here we describe the crystal structure of the alpha-subunit of OnTEBP in complex with T4G4 single-stranded telomeric DNA. This structure shows an (alpha--ssDNA)2 homodimer with a large approximately 7,000 A2 protein--protein interface in which the domains of alpha are rearranged extensively from their positions in the structure of an alpha--beta--ssDNA ternary complex. The (alpha--ssDNA)2 complex can bind two telomeres on opposite sides of the dimer and, thus, acts as a protein mediator of telomere--telomere associations. The structures of the (alpha--ssDNA)2 dimer presented here and the previously described alpha--beta--ssDNA complex demonstrate that OnTEBP forms multiple telomeric complexes that potentially mediate the assembly and disassembly of higher order telomeric structures.
About this Structure
1KIX is a Single protein structure of sequence from Sterkiella nova. Full crystallographic information is available from OCA.
Reference
Dimeric structure of the Oxytricha nova telomere end-binding protein alpha-subunit bound to ssDNA., Peersen OB, Ruggles JA, Schultz SC, Nat Struct Biol. 2002 Mar;9(3):182-7. PMID:11836536
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