Acetyl-CoA carboxylase
From Proteopedia
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| - | '''Acetyl-CoA carboxylase''' (ACC) catalyzes the irreversible carboxylation of acetyl-CoA to malonyl-CoA. Malonyl-CoA is a building block in in the biosynthesis of fatty acids. ACC is biotin- and ATP-dependent enzyme. ACC is a multi-subunit enzyme. Each subunit catalyzes different reaction. These are – biotin carboxylase (BC) which carboxylates the biotin prosthetic group see [[Biotin carboxylase]], biotin carboxyl carrier protein (BCCP) which is linked covalently to biotin and carboxyltransferase (CT) which transfers the carboxyl group from biotin to acetyl-CoA. In mammals, 2 forms of ACC exist. ACC1 and ACC2 differ in their tissue distribution and function. | + | '''Acetyl-CoA carboxylase''' (ACC) catalyzes the irreversible carboxylation of acetyl-CoA to malonyl-CoA. Malonyl-CoA is a building block in in the biosynthesis of fatty acids. ACC is biotin- and ATP-dependent enzyme. ACC is a multi-subunit enzyme. Each subunit catalyzes different reaction. These are – biotin carboxylase (BC) which carboxylates the biotin prosthetic group see [[Biotin carboxylase]], biotin carboxyl carrier protein (BCCP) which is linked covalently to biotin and carboxyltransferase (CT) which transfers the carboxyl group from biotin to acetyl-CoA. The biotindyl domain (residues 891-964 in human) transfers an activated carboxyl group from the BC domain to the CT domain. In mammals, 2 forms of ACC exist. ACC1 and ACC2 differ in their tissue distribution and function. |
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==3D structures of acetyl-CoA carboxylase== | ==3D structures of acetyl-CoA carboxylase== | ||
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**[[1a6x]], [[3bdo]] – EcBCCP – ''Escherichia coli'' – NMR<BR /> | **[[1a6x]], [[3bdo]] – EcBCCP – ''Escherichia coli'' – NMR<BR /> | ||
| - | **[[2dn8]] – | + | **[[2dn8]] – hBCCP2 – human - NMR<BR /> |
| + | **[[3glk]], [[3jrw]] – hBCCP2<br /> | ||
| + | **[[4hq6]] – hBCCP2 (mutant)<br /> | ||
| + | **[[2yl2]] – hBCCP1<br /> | ||
**[[1bdo]] - EcBCCP + biotin <BR /> | **[[1bdo]] - EcBCCP + biotin <BR /> | ||
**[[2bdo]] - EcBCCP + biotin – NMR<BR /> | **[[2bdo]] - EcBCCP + biotin – NMR<BR /> | ||
**[[1w93]] – yBCCP – yeast <br /> | **[[1w93]] – yBCCP – yeast <br /> | ||
**[[1w96]] – yBCCP + soraphen <br /> | **[[1w96]] – yBCCP + soraphen <br /> | ||
| + | **[[3gid]], [[3jrx]] – hBCCP2 + soraphen <br /> | ||
*Carboxyltransferase (CT) domain | *Carboxyltransferase (CT) domain | ||
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**[[1od2]] - yCT + adenine + acetyl CoA <BR /> | **[[1od2]] - yCT + adenine + acetyl CoA <BR /> | ||
**[[1od4]] - yCT + adenine<BR /> | **[[1od4]] - yCT + adenine<BR /> | ||
| - | **[[1uyr]], [[1uys]], [[1w2x]], [[3k8x]], [[3h0j]], [[3h0s]], [[3h0q]], [[3pgq]], [[3tv5]], [[3tvu]], [[3tvw]], [[3tz3]] - yCT + inhibitor<BR /> | + | **[[1uyr]], [[1uys]], [[1w2x]], [[3k8x]], [[3h0j]], [[3h0s]], [[3h0q]], [[3pgq]], [[3tv5]], [[3tvu]], [[3tvw]], [[3tz3]], [[4wyo]], [[4wz8]] - yCT + inhibitor<BR /> |
**[[2x24]] - CT + inhibitor – bovine | **[[2x24]] - CT + inhibitor – bovine | ||
| - | **[[3tdc]] – hACC2 residues 921-1676 | + | *ACC biotynyl domain (ACCBD) |
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| + | **[[2hjw]] – hACCBD2<br /> | ||
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| + | *ACC | ||
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| + | **[[2vpq]] – ACC – Staphylococcus aureus<br /> | ||
| + | **[[2w6p]] – EcACC + AMPPNP<br /> | ||
| + | **[[3tdc]] – hACC2 residues 921-1676 <br /> | ||
| + | **[[4asi]] – hACC1 C terminal<br /> | ||
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}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:25, 21 January 2015
Acetyl-CoA carboxylase (ACC) catalyzes the irreversible carboxylation of acetyl-CoA to malonyl-CoA. Malonyl-CoA is a building block in in the biosynthesis of fatty acids. ACC is biotin- and ATP-dependent enzyme. ACC is a multi-subunit enzyme. Each subunit catalyzes different reaction. These are – biotin carboxylase (BC) which carboxylates the biotin prosthetic group see Biotin carboxylase, biotin carboxyl carrier protein (BCCP) which is linked covalently to biotin and carboxyltransferase (CT) which transfers the carboxyl group from biotin to acetyl-CoA. The biotindyl domain (residues 891-964 in human) transfers an activated carboxyl group from the BC domain to the CT domain. In mammals, 2 forms of ACC exist. ACC1 and ACC2 differ in their tissue distribution and function.
3D structures of acetyl-CoA carboxylase
Updated on 21-January-2015
