3doe
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3doe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3doe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3doe RCSB], [http://www.ebi.ac.uk/pdbsum/3doe PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3doe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3doe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3doe RCSB], [http://www.ebi.ac.uk/pdbsum/3doe PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ARL2_HUMAN ARL2_HUMAN]] Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.<ref>PMID:10831612</ref> <ref>PMID:16525022</ref> <ref>PMID:18588884</ref> <ref>PMID:18234692</ref> <ref>PMID:20740604</ref> [[http://www.uniprot.org/uniprot/AR2BP_HUMAN AR2BP_HUMAN]] Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.<ref>PMID:18234692</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 17:08, 25 December 2014
Complex of ARL2 and BART, Crystal Form 1
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