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1l2q
From Proteopedia
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|PDB= 1l2q |SIZE=350|CAPTION= <scene name='initialview01'>1l2q</scene>, resolution 1.70Å | |PDB= 1l2q |SIZE=350|CAPTION= <scene name='initialview01'>1l2q</scene>, resolution 1.70Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=BGX:4-METHYL-PYRROLINE-5-CARBOXYLIC+ACID'>BGX</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=X7O:5-AMINO-3-METHYL-PYRROLIDINE-2-CARBOXYLIC+ACID'>X7O</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1l2r|1L2R]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2q OCA], [http://www.ebi.ac.uk/pdbsum/1l2q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l2q RCSB]</span> | ||
}} | }} | ||
| Line 28: | Line 31: | ||
[[Category: James, C M.]] | [[Category: James, C M.]] | ||
[[Category: Krzycki, J A.]] | [[Category: Krzycki, J A.]] | ||
| - | [[Category: BGX]] | ||
| - | [[Category: NH4]] | ||
| - | [[Category: X7O]] | ||
[[Category: tim barrel]] | [[Category: tim barrel]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:57:08 2008'' |
Revision as of 18:57, 30 March 2008
| |||||||
| , resolution 1.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Related: | 1L2R
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)
Overview
Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkeri monomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead it appears consistent with a lysine in amide-linkage to (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino acid be named l-pyrrolysine.
About this Structure
1L2Q is a Single protein structure of sequence from Methanosarcina barkeri. Full crystallographic information is available from OCA.
Reference
A new UAG-encoded residue in the structure of a methanogen methyltransferase., Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK, Science. 2002 May 24;296(5572):1462-6. PMID:12029132
Page seeded by OCA on Sun Mar 30 21:57:08 2008
