1l2q

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|PDB= 1l2q |SIZE=350|CAPTION= <scene name='initialview01'>1l2q</scene>, resolution 1.70&Aring;
|PDB= 1l2q |SIZE=350|CAPTION= <scene name='initialview01'>1l2q</scene>, resolution 1.70&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=X7O:5-AMINO-3-METHYL-PYRROLIDINE-2-CARBOXYLIC+ACID'>X7O</scene> and <scene name='pdbligand=BGX:4-METHYL-PYRROLINE-5-CARBOXYLIC ACID'>BGX</scene>
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|LIGAND= <scene name='pdbligand=BGX:4-METHYL-PYRROLINE-5-CARBOXYLIC+ACID'>BGX</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=X7O:5-AMINO-3-METHYL-PYRROLIDINE-2-CARBOXYLIC+ACID'>X7O</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=[[1l2r|1L2R]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2q OCA], [http://www.ebi.ac.uk/pdbsum/1l2q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l2q RCSB]</span>
}}
}}
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[[Category: James, C M.]]
[[Category: James, C M.]]
[[Category: Krzycki, J A.]]
[[Category: Krzycki, J A.]]
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[[Category: BGX]]
 
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[[Category: NH4]]
 
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[[Category: X7O]]
 
[[Category: tim barrel]]
[[Category: tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:25:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:57:08 2008''

Revision as of 18:57, 30 March 2008


PDB ID 1l2q

Drag the structure with the mouse to rotate
, resolution 1.70Å
Ligands: , ,
Related: 1L2R


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)


Overview

Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkeri monomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead it appears consistent with a lysine in amide-linkage to (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino acid be named l-pyrrolysine.

About this Structure

1L2Q is a Single protein structure of sequence from Methanosarcina barkeri. Full crystallographic information is available from OCA.

Reference

A new UAG-encoded residue in the structure of a methanogen methyltransferase., Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK, Science. 2002 May 24;296(5572):1462-6. PMID:12029132

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