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Actinin
From Proteopedia
| Line 16: | Line 16: | ||
**[[1h8b]] – haA2 EF hands+rTitin Z-repeat – rabbit<br /> | **[[1h8b]] – haA2 EF hands+rTitin Z-repeat – rabbit<br /> | ||
**[[1hc2]], [[1quu]] – haA2 SR<br /> | **[[1hc2]], [[1quu]] – haA2 SR<br /> | ||
| - | **[[1hci]] – haA2 repeats 1-4 | + | **[[1hci]] – haA2 repeats 1-4<br /> |
| + | **[[4d1e]] – haA2<br /> | ||
* α-actinin-3 (aA3) | * α-actinin-3 (aA3) | ||
Revision as of 13:47, 21 January 2015
Actinin attaches the protein actin to the Z-lines in skeletal muscle cells and to dense bodies in smooth muscle cells. Both ends of actinin contain an actin-binding domain (ABD). Actinin is encoded by different genes. ACTN1 encodes α-actinin-1 (aA1) which is a cytoskeletal isoform. ACTN2 encodes an isoform aA2 found in cardiac and skeletal muscles. For more details on ACTN2 see Group:MUZIC:actinin2. ACTN3 encodes aA3 which anchors actin at the muscle Z-disk. ACTN4 encodes aA4 which is found in the cytoplasm and is thought to be involved in metastasis. Actinins contain a 3-helix bundle which is called spectrin repeat (SR).
3D Structures of Actinin
Updated on 21-January-2015
