Adenosine deaminase

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'''Adenosine deaminase''' (ADA) deaminates adenosine and deoxyadenosine into inosine or deoxyinosine. ADA is part of the purine metabolism. In humans ADA is involved in the development and maintenance of the immune system. ADA deficiency is the cause of severe combined immunodeficiency (SCID). SCID was the first disorder to be treated by gene therapy. There are 2 isoforms of ADA: ADA1 and ADA2. ADA contains Zn+2 ion in its active site.
'''Adenosine deaminase''' (ADA) deaminates adenosine and deoxyadenosine into inosine or deoxyinosine. ADA is part of the purine metabolism. In humans ADA is involved in the development and maintenance of the immune system. ADA deficiency is the cause of severe combined immunodeficiency (SCID). SCID was the first disorder to be treated by gene therapy. There are 2 isoforms of ADA: ADA1 and ADA2. ADA contains Zn+2 ion in its active site.
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== 3D Structures of adenosine deaminase ==
== 3D Structures of adenosine deaminase ==

Revision as of 11:12, 12 November 2014

Structure of adenosine deaminase complex with Zn+2 (grey), acetonitrile and adenosine (stick model) (PDB entry 2pgf)

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3D Structures of adenosine deaminase

Updated on 12-November-2014

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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