Aerolysin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1pre.png|left|200px|thumb|Crystal Structure of Proaerolysin [[1pre]]]]
+
 
{{STRUCTURE_1pre| PDB=1pre | SIZE=400| SCENE=Aerolysin/Cv/1 |right|CAPTION=Proaerolysin dimer [[1pre]] }}
{{STRUCTURE_1pre| PDB=1pre | SIZE=400| SCENE=Aerolysin/Cv/1 |right|CAPTION=Proaerolysin dimer [[1pre]] }}
-
 
+
[[Aerolysin]] (Aer) is a channel-forming toxin from ''Aeromonas hydrophyla''. It uses GPI-anchored proteins on the cell surface as receptors. Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death. It is secreted as an inactive precursor proaerolysin (proAer) which gets cleaved by furin to produce the active Aer. For toxins in Proteopedia see [[Toxins]].
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
[[Aerolysin]] (Aer) is a channel-forming toxin from ''Aeromonas hydrophyla''. It uses GPI-anchored proteins on the cell surface as receptors. Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death. It is secreted as an inactive precursor proaerolysin (proAer) which gets cleaved by furin to produce the active Aer. The images at the left and at the right correspond to one representative Aerolysin, ''i.e.'' the crystal structure of Proaerolysin ([[1pre]]). For toxins in Proteopedia see [[Toxins]].
+
__NOTOC__
__NOTOC__

Revision as of 10:45, 28 October 2015

Template:STRUCTURE 1pre

Aerolysin (Aer) is a channel-forming toxin from Aeromonas hydrophyla. It uses GPI-anchored proteins on the cell surface as receptors. Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death. It is secreted as an inactive precursor proaerolysin (proAer) which gets cleaved by furin to produce the active Aer. For toxins in Proteopedia see Toxins.


3D Structures of Aerolysin

Updated on 28-October-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Aerolysin"
Personal tools