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Aldehyde dehydrogenase
From Proteopedia
(Difference between revisions)
| Line 74: | Line 74: | ||
*NAD-dependent ALDH | *NAD-dependent ALDH | ||
| - | + | **[[2w8n]], [[2w8o]], [[2w8r]] – Succinate–semi-hALDH family 5<BR /> | |
| - | + | **[[2w8p]] - Succinate–semi-hALDH family 5 (mutant) <BR /> | |
| - | + | **[[3r31]] – Betaine-ALDH – ''Agrobacterium tumefaciens''<BR /> | |
| - | + | **[[3ed6]], [[4mpb]], [[4nu9]] - Betaine-SaALDH – ''Staphylococcus aureus''<BR /> | |
| - | + | **[[1a4s]] - Betaine-cALDH - cod<BR /> | |
| - | + | **[[3llg]], [[3tz6]], [[3vos]] – Aspartate-semi-MtALDH<BR /> | |
| - | + | **[[2cq8]] - Formyltetrahydrofolate-hALDH PP-binding domain - NMR<BR /> | |
| - | + | **[[2nac]] – Formate-PsALDH<BR /> | |
| - | + | **[[3i44]] – ALDH – ''Bartonella henselae''<BR /> | |
| - | + | **[[3ek1]] – ALDH – ''Brucella melitensis''<br /> | |
| - | + | **[[3ros]] – ALDH – ''Lactobacillus acidophilus''<br /> | |
| - | + | **[[3r64]] – ALDH – ''Corynebacterium glutamicum''<br /> | |
| - | + | **[[3rhe]] – Benzaldehyde-ALDH – ''Legionella pneumophila''<br /> | |
| - | + | **[[3u4j]], [[4i3t]] – SmALDH – ''Sinorhizobium meliloti'' | |
| - | * | + | *NAD-dependent ALDH binary complexes |
| - | + | **[[2w8q]] - Succinate–semi-hALDH family 5 + succinic acid<BR /> | |
| - | + | **[[3fg0]], [[4mpy]], [[4nea]] - Betaine-SaALDH + NAD<BR /> | |
| - | + | **[[4ni4]] - Betaine-SaALDH (mutant) + NAD<br /> | |
| - | + | **[[1bpw]] - Betaine-cALDH + NAD<BR /> | |
| - | + | **[[2j6l]] – Aminoadipate-semi-hALDH family 7 + NAD<BR /> | |
| - | + | **[[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR /> | |
| - | + | **[[2nad]] - Formate-PsALDH + NAD – ''Pseudomonas''<BR /> | |
| - | + | **[[1bi9]] – Retinal-rALDH2 + NAD<BR /> | |
| - | + | **[[3l4p]], [[1sij]] – ALDH + AsO3 – ''Desulfovibrio gigas''<br /> | |
| - | + | **[[4a0m]] – spALDH + NAD – spinach<br /> | |
| - | + | **[[3iwk]] – amino-ALDH + NAD – pea<br /> | |
| - | + | **[[3ju8]] - Succinylglutamic–semi-PaALDH + NAD – ''Pseudomonas aeruginosa''<br /> | |
| - | + | **[[4c3s]] - ALDH + NAD – ''Clostridium phytofermentans''<br /> | |
| - | + | **[[4i3u]] – SmALDH + phosphonoacetaldehyde<br /> | |
| - | * | + | *NAD-dependent ALDH ternary complexes |
| - | + | **[[2gsd]] – Formate-ALDH + NAD + azide – ''Moraxella''<BR /> | |
| - | + | **[[1nvm]] – Acetaldehyde-PsALDH + 4-hydroxy-oxovalerate aldolase + NAD<BR /> | |
| - | + | **[[1llu]] - PaALDH + NAD + alcohol<br /> | |
| - | + | **[[4i3v]], [[4i3w]] – SmALDH + aldehyde derivative + NAD<br /> | |
| - | + | **[[4i3x]] – SmALDH + phosphonoacete + NAD<br /> | |
*NADP-dependent ALDH | *NADP-dependent ALDH | ||
| - | + | **[[3k2w]] - Betaine-ALDH – ''Pseudoalteromonas atlantica''<BR /> | |
| - | + | **[[2hg2]], [[2opx]] – Lactaldehyde-EcALDH <BR /> | |
| - | + | **[[2o2p]] – Formyltetrahydrofolate-rALDH C-terminal<br /> | |
| - | + | **[[2y51]], [[2y52]], [[2y53]], [[2y5d]] – BxALDH (mutant) – ''Burkholderia xenovorans''<br /> | |
| - | + | **[[3ifg]], [[3ifh]] - Succinate–semi-ALDH – ''Burkholderia pseudomallei''<br /> | |
| - | + | **[[3rh9]] - Succinate–semi-ALDH – ''Marinobacter aquaeolei''<br /> | |
| - | + | **[[3uw3]] - aspartate–semi-ALDH – ''Burkholderia thailandensis''<br /> | |
| - | + | **[[3v4c]] - SmALDH | |
| - | * | + | *NADP-dependent ALDH binary complexes |
| - | + | **[[2wox]], [[2wme]], [[2xdr]], [[3zqa]] - Betaine-PaALDH + NADP<BR /> | |
| - | + | **[[3lv1]] – Benzaldehyde-PpALDH3 + NADP – ''Pseudomonas putida''<BR /> | |
| - | + | **[[2ilu]] - Lactaldehyde-EcALDH + NADP<BR /> | |
| - | + | **[[3rhd]] - Lactaldehyde-MjALDH + NADP - ''Methanocaldococcus jannaschii''<br /> | |
| - | + | **[[2o2q]], [[2o2r]] - Formyltetrahydrofolate-rALDH C-terminal + NADP<BR /> | |
| - | + | **[[3b4w]] - MtALDH + NADP – ''Mycobacterium tuberculosis''<BR /> | |
| - | + | **[[1eyy]], [[1ez0]] – ALDH + NADP – ''Vibrio harveyi''<br /> | |
| - | + | **[[3jz4]] - Succinate–semi-EcALDH + NADP<br /> | |
| - | + | **[[3hsk]] - aspartate–semi-ALDH + NADP – ''Candida albicans''<br /> | |
| - | + | **[[4h73]] - ALDH + NADP – ''Pyrobaculum''<br /> | |
| - | * | + | *NADP-dependent ALDH ternary complexes |
| - | + | **[[3lns]] - Benzaldehyde-PpALDH3 + NADP + benzoate<BR /> | |
| - | + | **[[2imp]] - Lactaldehyde-EcALDH + NADH + lactate<BR /> | |
| - | + | **[[2vro]] – BxALDH + NADP + alcohol | |
| - | + | **[[3k9d]] – ALDH – ''Listeria monocytogenes'' | |
*Antiquitin | *Antiquitin | ||
Revision as of 09:19, 16 November 2014
Image:1nzx.png
Crystal Structure of Aldehyde dehydrogenase, 1nzx
Aldehyde dehydrogenase (ALDH) converts aldehydes to carboxylic acids while reducing NAD+ to NADH. In mammals there are 3 classes of ALDH and each contain constitutive and inducible forms.
- ALDH class 1 is cytosolic.
- ALDH class 2 is mitochondrial.
- ALDH class 3 is found in tumors, stomach and cornea. ALDH3A1 is soluble and has substrate specificity to bulky aromatic aldehydes. ALDH3A2 is a fatty ALDH (FALDH). FALDH was found to have an additional gatekeeper helix at the substrate funnel entrance that is shaping the enzymes substrate specificity. [1]
- ALDH family 7 member A1 is known as antiquitin and functions in the detoxification of aldehydes.
3D Structures of Aldehyde dehydrogenase
Updated on 16-November-2014
References
- ↑ Keller, Markus A.; Zander, Ulrich; Fuchs, Julian E.; Kreutz, Christoph; Watschinger, Katrin et al. (2014). A gatekeeper helix determines the substrate specificity of Sjögren–Larsson Syndrome enzyme fatty aldehyde dehydrogenase. Nature Communications vol. 5.
