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Aminoacyl tRNA Synthetase

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**[[1iq0]] – TtArgRS - ''Thermus thermophilus''
**[[1iq0]] – TtArgRS - ''Thermus thermophilus''
-
*Arg-RS + tRNA
+
*''Arg-RS + tRNA''
**[[2zuf]] - PhArgRS + Arg-tRNA - ''Pyrococcus horikoshii''<br />
**[[2zuf]] - PhArgRS + Arg-tRNA - ''Pyrococcus horikoshii''<br />
**[[1f7v]] - yArgRS + Arg-tRNA
**[[1f7v]] - yArgRS + Arg-tRNA
-
*Arg-RS ternary complex
+
*''Arg-RS ternary complex''
**[[1f7u]] – yArgRS + Arg-tRNA + Arg<br />
**[[1f7u]] – yArgRS + Arg-tRNA + Arg<br />
Line 59: Line 59:
**[[1li7]] - EcCysRS + Cys<br />
**[[1li7]] - EcCysRS + Cys<br />
**[[1u0b]] – EcCysRS + Cys-tRNA
**[[1u0b]] – EcCysRS + Cys-tRNA
-
}}
 
-
===Gln-RS===
 
-
[[1nyl]]– EcGlnRS<br />
+
*Gln-RS
-
[[2gls]], [[1lgr]] – StGlnRS – ''Salmonella typhimurium''<br />
+
 
-
[[2lgs]] – StGlnRS + Glu<br />
+
**[[1nyl]]– EcGlnRS<br />
-
[[1qrt]], [[ 1qru]], [[1qrs]] - EcGlnRS (mutant) + Gln-tRNA<br />
+
**[[2gls]], [[1lgr]] – StGlnRS – ''Salmonella typhimurium''<br />
-
[[1gtr]], [[ 1gts]], [[ 1gsg]] - EcGlnRS + Gln-tRNA<br />
+
**[[2lgs]] – StGlnRS + Glu<br />
-
[[1qtq]] - EcGlnRS + Gln-tRNA + Gln analog
+
**[1qrt]], [[1qru]], [[1qrs]] - EcGlnRS (mutant) + Gln-tRNA<br />
 +
**[[1gtr]], [[1gts]], [[1gsg]] - EcGlnRS + Gln-tRNA<br />
 +
**[[1qtq]] - EcGlnRS + Gln-tRNA + Gln analog
-
''Gln-RS ternary complex''
+
*''Gln-RS ternary complex''
-
[[1euq]], [[ 1euy]] – EcGlnRS + Gln-tRNA + Gln-SA<br />
+
**[[1euq]], [[ 1euy]] – EcGlnRS + Gln-tRNA + Gln-SA<br />
-
[[1exd]] - EcGlnRS + Gln-tRNA (mutant) + AMP
+
**[[1exd]] - EcGlnRS + Gln-tRNA (mutant) + AMP
-
===Glu-RS===
+
*Glu-RS
-
[[1gln]] – TtGluRS<br />
+
**[[1gln]] – TtGluRS<br />
-
[[2o5r]] - TmGluRS<br />
+
**[[2o5r]] - TmGluRS<br />
-
[[3aii]] – GluRS – ''Methanothermobacter thermautotrophicus''<br />
+
**[[3aii]] – GluRS – ''Methanothermobacter thermautotrophicus''<br />
-
[[2ja2]] – MtGluRS – ''Mycobacterium tuberculosis''<br />
+
**[[2ja2]] – MtGluRS – ''Mycobacterium tuberculosis''<br />
-
[[2zlz]] – EcGluRS<br />
+
**[[2zlz]] – EcGluRS<br />
-
[[2hz7]] – DrGluRS – ''Deinococcus radiodurans''<br />
+
**[[2hz7]] – DrGluRS – ''Deinococcus radiodurans''<br />
-
[[2hra]] – yGluRS N-terminal
+
**[[2hra]] – yGluRS N-terminal
-
''Glu-RS + small substrates or analogs''
+
*''Glu-RS + small substrates or analogs''
-
[[3afh]] - TmGluRS + Glu-AMP analog<br />
+
**[[3afh]] - TmGluRS + Glu-AMP analog<br />
-
[[2rd2]], [[ 2re8]] – EcGluRS (mutant) + Glu-SA<br />
+
**[[2rd2]], [[ 2re8]] – EcGluRS (mutant) + Glu-SA<br />
-
[[2cuz]] – TtGluRS + Glu<br />
+
**[[2cuz]] – TtGluRS + Glu<br />
-
[[1j09]] - TtGluRS + Glu + ATP<br />
+
**[[1j09]] - TtGluRS + Glu + ATP<br />
-
[[1n75]] - TtGluRS + ATP<br />
+
**[[1n75]] - TtGluRS + ATP<br />
-
[[2fco]] - GluRS residues 2-485 + Glu – ''Synechococcus elongatus''
+
**[[2fco]] - GluRS residues 2-485 + Glu – ''Synechococcus elongatus''
-
''Glu-RS + tRNA''
+
*''Glu-RS + tRNA''
-
[[1zjw]] – EcGluRS + Glu-tRNA
+
**[[1zjw]] – EcGluRS + Glu-tRNA
-
''Glu-RS ternary complex''
+
*''Glu-RS ternary complex''
-
[[3akz]], [[ 3al0]] – TmGluRS + tRNA + Glu-AMP analog – ''Thermotoga maritima''<br />
+
**[[3akz]], [[ 3al0]] – TmGluRS + tRNA + Glu-AMP analog – ''Thermotoga maritima''<br />
-
[[1o0b]], [[ 1o0c]] - EcGluRS + Glu-tRNA + Glu + AMP<br />[[2cv0]], [[ 1n77]] - TtGluRS + Glu + Glu-tRNA<br />
+
**[[1o0b]], [[ 1o0c]] - EcGluRS + Glu-tRNA + Glu + AMP<br />[[2cv0]], [[ 1n77]] - TtGluRS + Glu + Glu-tRNA<br />
-
[[1n78]] - TtGluRS + Glu-ol + Glu-tRNA<br />
+
**[[1n78]] - TtGluRS + Glu-ol + Glu-tRNA<br />
-
[[2cv1]] - TtGluRS + Glu-ol + ATP + Glu-tRNA<br />
+
**[[2cv1]] - TtGluRS + Glu-ol + ATP + Glu-tRNA<br />
-
[[2cv2]] - TtGluRS + Glu-SA + Glu-tRNA<br />
+
**[[2cv2]] - TtGluRS + Glu-SA + Glu-tRNA<br />
-
[[2hrk]], [[ 2hsm]] - yGluRS N-terminal + GU4 nucleic-binding protein 1
+
**[[2hrk]], [[ 2hsm]] - yGluRS N-terminal + GU4 nucleic-binding protein 1
-
===Ile-RS===
+
*Ile-RS
-
[[1ile]] - TtIleRS<br />
+
**[[1ile]] - TtIleRS<br />
-
[[1wny]], [[ 1udz]] – TtIleRS editing domain
+
**[[1wny]], [[ 1udz]] – TtIleRS editing domain
-
''Ile-RS + small substrates or analogs''<br />
+
*''Ile-RS + small substrates or analogs''<br />
-
[[1ue0]] - TtIleRS editing domain + Val<br />
+
**[[1ue0]] - TtIleRS editing domain + Val<br />
-
[[1wnz]] - TtIleS editing domain + Val-adenylate<br />
+
**[[1wnz]] - TtIleS editing domain + Val-adenylate<br />
-
[[1wk8]] - TtIleRS editing domain + Val-SA<br />
+
**[[1wk8]] - TtIleRS editing domain + Val-SA<br />
-
[[1jzq]] – TtIleS + Ile-adenylate analog<br />
+
**[[1jzq]] – TtIleS + Ile-adenylate analog<br />
-
[[1jzs]] – TtIleS + antibiotic
+
**[[1jzs]] – TtIleS + antibiotic
-
''Ile-RS ternary complex''<br />
+
*''Ile-RS ternary complex''<br />
-
[[1ffy]], [[ 1qu2]], [[ 1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus''
+
**[[1ffy]], [[ 1qu2]], [[ 1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus''
-
===Leu-RS===
+
*Leu-RS
-
[[3o0a]] – AaLeuRS hydrolytic domain – ''Aquifex aeolicus''<br />[[2wfd]] – hLeuRS editing domain – human<br />
+
**[[3o0a]] – AaLeuRS hydrolytic domain – ''Aquifex aeolicus''<br />[[2wfd]] – hLeuRS editing domain – human<br />
-
[[2wfe]] - CaLeuRS editing domain – ''Candida albicans''<br />
+
**[[2wfe]] - CaLeuRS editing domain – ''Candida albicans''<br />
-
[[2ajg]] - EcLeuRS editing domain<br />
+
**[[2ajg]] - EcLeuRS editing domain<br />
-
[[1wkb]] – PhLeuRS residues 1-810
+
**[[1wkb]] – PhLeuRS residues 1-810
-
''Leu-RS + small substrates or analogs''<br />
+
*''Leu-RS + small substrates or analogs''<br />
-
[[2wfg]] - CaLeuRS editing domain + benzoxaborole-AMP<br />
+
**[[2wfg]] - CaLeuRS editing domain + benzoxaborole-AMP<br />
-
[[2v0c]] – TtLeuRS + Leu-SA + benzoxaborole-AMP<br />
+
**[[2v0c]] – TtLeuRS + Leu-SA + benzoxaborole-AMP<br />
-
[[1h3n]] - TtLeuRS + Leu-SA<br />
+
**[[1h3n]] - TtLeuRS + Leu-SA<br />
-
[[1obc]], [[ 1obh]] – TtLeuRS + substrate analog<br />
+
**[[1obc]], [[1obh]] – TtLeuRS + substrate analog<br />
-
[[2ajh]], [[ 2aji]] - EcLeuRS editing domain + aa
+
**[[2ajh]], [[2aji]] - EcLeuRS editing domain + aa
-
''Leu-RS + tRNA''<br />
+
*''Leu-RS + tRNA''<br />
-
[[1wz2]] – PhLeuRS Leu-tRNA
+
**[[1wz2]] – PhLeuRS Leu-tRNA
-
''Leu-RS ternary complex''<br />
+
*''Leu-RS ternary complex''<br />
-
[[2v0g]] - TtLeuRS + Leu-tRNA + benzoxaborole-AMP<br />
+
**[[2bte]], [[ 2byt]] - TtLeuRS + Leu-tRNA + Leu
-
[[2bte]], [[ 2byt]] - TtLeuRS + Leu-tRNA + Leu
+
-
===Lys-RS===
+
*Lys-RS
-
[[1irx]] – PhLysRS<br />
+
**[[1irx]] – PhLysRS<br />
-
[[1bbw]] – EcLysRS<br />
+
**[[1bbw]] – EcLysRS<br />
-
[[1krs]], [[ 1krt]] – EcLysRS anticodon-binding domain – NMR<br />[[3dsq]] – DhLysRS – ''Desulfitobacterium hafniense''<br />
+
**[[1krs]], [[ 1krt]] – EcLysRS anticodon-binding domain – NMR<br />[[3dsq]] – DhLysRS – ''Desulfitobacterium hafniense''<br />
-
[[2e3c]] - MmLysRS catalytic domain - ''Methanosarcina mazei''<br />
+
**[[2e3c]] - MmLysRS catalytic domain - ''Methanosarcina mazei''<br />
-
[[3bju]] – hLysRS residues 70-579
+
**[[3bju]] – hLysRS residues 70-579
-
''Lys-RS + small substrates or analogs''<br />
+
*''Lys-RS + small substrates or analogs''<br />
-
[[3a74]] – GsLysRS + diadenosine tetraphosphate – ''Geobacillus stearothermophilus''<br />
+
**[[3a74]] – GsLysRS + diadenosine tetraphosphate – ''Geobacillus stearothermophilus''<br />
-
[[3e9h]], [[ 3e9i]] – BsLysRS + Lys-SA - ''Bacillus stearothermophilus''<br />
+
**[[3e9h]], [[3e9i]] – BsLysRS + Lys-SA - ''Bacillus stearothermophilus''<br />
-
[[2zin]] – MmLysRS catalytic domain + Boc-Lys + ATP analog<br />
+
**[[2zin]] – MmLysRS catalytic domain + Boc-Lys + ATP analog<br />
-
[[2zio]] - MmLysRS catalytic domain + Aloc-Lys-AMP + PNP<br />
+
**[[2zio]] - MmLysRS catalytic domain + Aloc-Lys-AMP + PNP<br />
-
[[2zcd]] - MmLysRS catalytic domain + AMPPNP<br />
+
**[[2zcd]] - MmLysRS catalytic domain + AMPPNP<br />
-
[[2zce]] - MmLysRS catalytic domain + pyrro-Lys + ATP analog<br />
+
**[[2zce]] - MmLysRS catalytic domain + pyrro-Lys + ATP analog<br />
-
[[2zim]] - MmLysRS residues 185-454+ pyrro-Lys-adenylate<br />
+
**[[2zim]] - MmLysRS residues 185-454+ pyrro-Lys-adenylate<br />
-
[[2q7e]] - MmLysRS C-terminal + ATP analog<br />
+
**[[2q7e]] - MmLysRS C-terminal + ATP analog<br />
-
[[2q7g]] - MmLysRS C-terminal+ pyrro-Lys analog+ ATP <br />
+
**[[2q7g]] - MmLysRS C-terminal+ pyrro-Lys analog+ ATP <br />
-
[[1bbu]], [[ 1e10]], [[ 1lyl]] – EcLysRS + Lys<br />
+
**[[1bbu]], [[1e10]], [[1lyl]] – EcLysRS + Lys<br />
-
[[1e1t]] - EcLysRS + Lys-adenylate<br />
+
**[[1e1t]] - EcLysRS + Lys-adenylate<br />
-
[[1e22]] - EcLysRS + Lys + AMPPCP<br />
+
**[[1e22]] - EcLysRS + Lys + AMPPCP<br />
-
[[1e24]] - EcLysRS + Lys + ATP
+
**[[1e24]] - EcLysRS + Lys + ATP
-
''Leu-RS + tRNA''<br />
+
*''Leu-RS + tRNA''<br />
-
[[2zni]], [[ 2znj]] – DhLysRS + tRNA
+
**[[2zni]], [[2znj]] – DhLysRS + tRNA
-
===Met-RS===
+
*Met-RS
-
[[1a8h]] – TtMetRS<br />
+
**[[1a8h]] – TtMetRS<br />
-
[[1med]], [[1mea]] – EcMetRS Zinc-binding domain - NMR<br />
+
**[[1med]], [[1mea]] – EcMetRS Zinc-binding domain - NMR<br />
-
[[1qqt]] - EcMetRS residues 2-552<br />
+
**[[1qqt]] - EcMetRS residues 2-552<br />
-
[[2x1l]] - MsMetRS residues 2-515 – ''Mycobacterium smegmatis''<br />
+
**[[2x1l]] - MsMetRS residues 2-515 – ''Mycobacterium smegmatis''<br />
-
[[3h97]] – EcMetRS residues 2-548 (mutant) <br />
+
**[[3h97]] – EcMetRS residues 2-548 (mutant) <br />
-
[[3h9c]] - EcMetRS residues 2-548<br />
+
**[[3h9c]] - EcMetRS residues 2-548<br />
-
[[2d54]], [[ 2d5b]] – TtMetRS (mutant) <br />
+
**[[2d54]], [[2d5b]] – TtMetRS (mutant) <br />
-
[[1woy]] – TtMetRS residues 1-500 (mutant) <br />
+
**[[1woy]] – TtMetRS residues 1-500 (mutant) <br />
-
[[2djv]] – hMetRS WHEP-TRS domain – NMR<br />
+
**[[2djv]] – hMetRS WHEP-TRS domain – NMR<br />
-
[[1pyb]] – AaMetRS β subunit<br />
+
**[[1pyb]] – AaMetRS β subunit<br />
-
[[1rqg]] – PaMetRS – ''Pyrococcus abyssi''<br />
+
**[[1rqg]] – PaMetRS – ''Pyrococcus abyssi''<br />
-
[[1mkh]] – PaMetRS C-terminal
+
**[[1mkh]] – PaMetRS C-terminal
-
''Met-RS + small substrates or analogs''<br />
+
*''Met-RS + small substrates or analogs''<br />
-
[[3kfl]] – LmMetRS residues 206-747+ Met-adenylate - ''Leishmania major''<br />
+
**[[3kfl]] – LmMetRS residues 206-747+ Met-adenylate - ''Leishmania major''<br />
-
[[2x1m]] - MsMetRS residues 2-515 + Met<br />
+
**[[2x1m]] - MsMetRS residues 2-515 + Met<br />
-
[[1p7p]], [[ 1pfu]], [[ 1pfv]], [[ 1pfw]] - EcMetRS residues 2-548 + Met<br />
+
**[[1p7p]], [[1pfu]], [[1pfv]], [[1pfw]] - EcMetRS residues 2-548 + Met<br />
-
[[1pfy]] - EcMetRS residues 1-551 + Met-SA<br />
+
**[[1pfy]] - EcMetRS residues 1-551 + Met-SA<br />
-
[[1f4l]] - EcMetRS residues 1-551 + Met<br />
+
**[[1f4l]] - EcMetRS residues 1-551 + Met<br />
-
[[1pg0]] - EcMetRS residues 1-551 + Met-adenylate<br />
+
**[[1pg0]] - EcMetRS residues 1-551 + Met-adenylate<br />
-
[[1pg2]] - EcMetRS residues 1-551 + Met + adenine<br />
+
**[[1pg2]] - EcMetRS residues 1-551 + Met + adenine<br />
-
[[3h99]] - EcMetRS residues 2-548 (mutant) + Met<br />
+
**[[3h99]] - EcMetRS residues 2-548 (mutant) + Met<br />
-
[[3h9b]] - EcMetRS residues 2-548 (mutant) + azidonorleucine<br />
+
**[[3h9b]] - EcMetRS residues 2-548 (mutant) + azidonorleucine<br />
-
[[4dlp]] - MetRS + SMet – ''Brucella melitensis''
+
**[[4dlp]] - MetRS + SMet – ''Brucella melitensis''
-
''Met-RS + tRNA''<br />
+
*''Met-RS + tRNA''<br />
-
[[2csx]] – AaMetRS + Met-tRNA
+
**[[2csx]] – AaMetRS + Met-tRNA
-
''Met-RS + tRNA''<br />
+
*''Met-RS + tRNA''<br />
-
[[2ct8]] - AaMetRS + Met-tRNA + Met-SA<br />
+
**[[2ct8]] - AaMetRS + Met-tRNA + Met-SA<br />
-
[[2dxi]] – TtMetRS + tRNA + ATP + Glu-ol
+
**[[2dxi]] – TtMetRS + tRNA + ATP + Glu-ol
-
[[2hsn]] - yMetRS N-terminal + GU4 nucleic-binding protein 1 N-terminal
+
**[[2hsn]] - yMetRS N-terminal + GU4 nucleic-binding protein 1 N-terminal
-
===Trp-RS===
+
*Trp-RS
-
[[1d2r]] - GsTrpRS<br />
+
**[[1d2r]] - GsTrpRS<br />
-
[[3prh]] – TrpRS (mutant) – ''Bacillus subtilis''<br />
+
**[[3prh]] – TrpRS (mutant) – ''Bacillus subtilis''<br />
-
[[3n9i]] – TrpRS – ''Yarsinia pestis''<br />
+
**[[3n9i]] – TrpRS – ''Yarsinia pestis''<br />
-
[[3m5w]] – CjTrpRS – ''Campylobacter jejuni''<br />
+
**[[3m5w]] – CjTrpRS – ''Campylobacter jejuni''<br />
-
[[3a04]] – ApTrpRS – ''Aeropyrum pernix''<br />
+
**[[3a04]] – ApTrpRS – ''Aeropyrum pernix''<br />
-
[[3hzr]] – EhTrpRS – ''Entamoeba histolytica'' <br />
+
**[[3hzr]] – EhTrpRS – ''Entamoeba histolytica'' <br />
-
[[3i05]] – TbTrpRS residues 3-389 – ''Trypanosoma brucei''<br />
+
**[[3i05]] – TbTrpRS residues 3-389 – ''Trypanosoma brucei''<br />
-
[[3hv0]] – TRrpS residues 206-593 – ''Cryptosporidium parvum''<br />
+
**[[3hv0]] – TRrpS residues 206-593 – ''Cryptosporidium parvum''<br />
-
[[3foc]] – GlTrpRS – ''Giardia lamblia''<br />
+
**[[3foc]] – GlTrpRS – ''Giardia lamblia''<br />
-
[[1o5t]] – hTrpRS catalytic fragment<br />
+
**[[1o5t]] – hTrpRS catalytic fragment<br />
-
[[1ulh]] – hTrpRS residues 35-424<br />
+
**[[1ulh]] – hTrpRS residues 35-424<br />
-
[[2el7]] – TtTrpRS<br />
+
**[[2el7]] – TtTrpRS<br />
-
[[2ip1]], [[3kt0]] – yTrpRS – yeast<br />
+
**[[2ip1]], [[3kt0]] – yTrpRS – yeast<br />
-
[[2yy5]] – TrpRS – ''Mycoplasma pneumoniae''<br />
+
**[[2yy5]] – TrpRS – ''Mycoplasma pneumoniae''<br />
-
[[2g36]] – TmTrpRS<br />
+
**[[2g36]] – TmTrpRS<br />
-
[[1bks]] – StTrpRS + pyridoxal phosphate
+
**[[1bks]] – StTrpRS + pyridoxal phosphate
-
''Trp-RS + small substrates or analogs''<br />
+
*''Trp-RS + small substrates or analogs''<br />
-
[[3a05]] – ApTrpRS + Trp<br />
+
**[[3a05]] – ApTrpRS + Trp<br />
-
[[3kt3]] – yTrpRS + Trp-adenylate<br />
+
**[[3kt3]] – yTrpRS + Trp-adenylate<br />
-
[[3kt6]], [[ 3kt8]] – yTrpRS + Trp<br />
+
**[[3kt6]], [[3kt8]] – yTrpRS + Trp<br />
-
[[3jxe]] – PhTrpRS + Trp-adenylate<br />
+
**[[3jxe]] – PhTrpRS + Trp-adenylate<br />
-
[[3fhj]], [[ 3fio]] – BsTrpRS + Trp + AMP + Pi<br />
+
**[[3fhj]], [[3fio]] – BsTrpRS + Trp + AMP + Pi<br />
-
[[2quh]] – hTrpRS + Trp<br />
+
**[[2quh]] – hTrpRS + Trp<br />
-
[[2qui]] - hTrpRS + Trp-amide + ATP<br />
+
**[[2qui]] - hTrpRS + Trp-amide + ATP<br />
-
[[2quj]] - hTrpRS + Trp-adenylate<br />
+
**[[2quj]] - hTrpRS + Trp-adenylate<br />
-
[[2quk]] – hTrpRS + ATP<br />
+
**[[2quk]] – hTrpRS + ATP<br />
-
[[2ov4]] – GsTrpRS + adenosine tetraphosphate<br />
+
**[[2ov4]] – GsTrpRS + adenosine tetraphosphate<br />
-
[[1i6k]], [[ 1i6l]], [[ 1i6m]] – GsTrpRS + Trp-adenylate<br />
+
**[[1i6k]], [[1i6l]], [[1i6m]] – GsTrpRS + Trp-adenylate<br />
-
[[1yid]], [[ 2a4m]] – DrTrpRS + ATP<br />
+
**[[1yid]], [[2a4m]] – DrTrpRS + ATP<br />
-
[[1yi8]], [[ 1yia]] – DrTrpRS + Trp<br />
+
**[[1yi8]], [[1yia]] – DrTrpRS + Trp<br />
-
[[1mau]] – GsTrpRS + Trp + ATP<br />
+
**[[1mau]] – GsTrpRS + Trp + ATP<br />
-
[[1maw]], [[ 1m83]] - GsTrpRS + ATP<br />
+
**[[1maw]], [[ 1m83]] - GsTrpRS + ATP<br />
-
[[1mb2]] - GsTrpRS + Trp <br />
+
**[[1mb2]] - GsTrpRS + Trp <br />
-
[[3tze]] - TrpRS + Trp - ''Encephalitozoon cuniculi''<br />
+
**[[3tze]] - TrpRS + Trp - ''Encephalitozoon cuniculi''<br />
-
[[3tzl]] - CjTrpRS + Trp + ADP<br />
+
**[[3tzl]] - CjTrpRS + Trp + ADP<br />
-
[[3sz3]] - TrpRS + Trp - ''Vibrio cholerae''<br />
+
**[[3sz3]] - TrpRS + Trp - ''Vibrio cholerae''<br />
-
''Trp-RS + tRNA''<br />
+
*''Trp-RS + tRNA''<br />
-
[[2azx]] – hTrpRS (mutant) + tRNA<br />
+
**[[2ake]], [[2dr2]] - hTrpRS + Trp-tRNA
-
[[2ake]], [[ 2dr2]] - hTrpRS + Trp-tRNA
+
-
===Tyr-RS===
+
*Tyr-RS
-
[[1tya]], [[ 1tyb]], [[ 1tyc]], [[ 1tyd]], [[ 2ts1]] – GsTyrRS<br />
+
**[[1tya]], [[ 1tyb]], [[ 1tyc]], [[ 1tyd]], [[ 2ts1]] – GsTyrRS<br />
-
[[3qe4]], [[ 3d6u]], [[ 3d6v]], [[ 2pxh]], [[ 2hgz]], [[ 1u7d]] – MjTyrRS – ''Methanocaldococcus jannaschii''<br />
+
**[[3qe4]], [[3d6u]], [[3d6v]], [[2pxh]], [[2hgz]], [[1u7d]] – MjTyrRS – ''Methanocaldococcus jannaschii''<br />
-
[[1u7x]], [[4hjr]], [[4hk4]]- MjTyrRS (mutant) <br />
+
**[[1u7x]], [[4hjr]], [[4hk4]]- MjTyrRS (mutant) <br />
-
[[2jan]] – MtTyrRS<br />
+
**[[2jan]] – MtTyrRS<br />
-
[[1y42]] - NcTyrRS – ''Neurospora crassa''<br />
+
**[[1y42]] - NcTyrRS – ''Neurospora crassa''<br />
-
[[2cya]] – ApTyrRS<br />
+
**[[2cya]] – ApTyrRS<br />
-
[[1n3l]] - hTyrRS residues 1-364<br />
+
**[[1n3l]] - hTyrRS residues 1-364<br />
-
[[1r6t]], [[ 1r6u]] – yTyrRS (mutant) <br />
+
**[[1r6t]], [[1r6u]] – yTyrRS (mutant) <br />
-
[[1jh3]] – GsTyrRS C-terminal – NMR<br />
+
**[[1jh3]] – GsTyrRS C-terminal – NMR<br />
-
''Tyr-RS + small substrates or analogs''<br />
+
*''Tyr-RS + small substrates or analogs''<br />
-
[[3ts1]] – GsTyrRS + Tyr-adenylate intermediate<br />
+
**[[3ts1]] – GsTyrRS + Tyr-adenylate intermediate<br />
-
[[4ts1]] – GsTyrRS + Tyr<br />
+
**[[4ts1]] – GsTyrRS + Tyr<br />
-
[[3p0h]], [[ 3p0i]], [[ 3p0j]] – LmTyrRS + inhibitor<br />
+
**[[3p0h]], [[3p0i]], [[3p0j]] – LmTyrRS + inhibitor<br />
-
[[3n2y]] – MjTyrRS + tetrazolyl phenylalanine<br />
+
**[[3n2y]] – MjTyrRS + tetrazolyl phenylalanine<br />
-
[[2zp1]] – MjTyrRS (mutant) + Tyr<br />
+
**[[2zp1]] – MjTyrRS (mutant) + Tyr<br />
-
[[1zh0]] - MjTyrRS (mutant) + naphthyl-Ala<br />
+
**[[1zh0]] - MjTyrRS (mutant) + naphthyl-Ala<br />
-
[[1zh6]] - MjTyrRS (mutant) + acetyl-Phe<br />
+
**[[1zh6]] - MjTyrRS (mutant) + acetyl-Phe<br />
-
[[2ag6]] - MjTyrRS (mutant) + bromo-Phe<br />
+
**[[2ag6]] - MjTyrRS (mutant) + bromo-Phe<br />
-
[[4hjx]] - MjTyrRS (mutant) + di-fluoro-Tyr<br />
+
**[[4hjx]] - MjTyrRS (mutant) + di-fluoro-Tyr<br />
-
[[2yxn]] – EcTyrRS residues 1-322 + azido-Tyr<br />
+
**[[2yxn]] – EcTyrRS residues 1-322 + azido-Tyr<br />
-
[[1vbm]] – EcTyrRS + Tyr-SA<br />
+
**[[1vbm]] – EcTyrRS + Tyr-SA<br />
-
[[1vbn]] – EcTyrRS (mutant) + Tyr-SA<br />
+
**[[1vbn]] – EcTyrRS (mutant) + Tyr-SA<br />
-
[[1wq3]], [[ 1wq4]] - EcTyrRS (mutant) + Tyr<br />
+
**[[1wq3]], [[1wq4]] - EcTyrRS (mutant) + Tyr<br />
-
[[1x8x]] – EcTyrRS + Tyr<br />[[2pid]] – hTyrRS residues 28-375 + Tyr-SA<br />
+
**[[1x8x]] – EcTyrRS + Tyr<br />
-
[[2j5b]] – TyrRS residues 2-346 + Tyr-ol – ''Acanthamoeba polyphaga'' minivirus<br />
+
**[[2pid]] – hTyrRS residues 28-375 + Tyr-SA<br />
-
[[2dlc]] – yTyrRS + tRNA + Tyr-SA<br />
+
**[[2j5b]] – TyrRS residues 2-346 + Tyr-ol – ''Acanthamoeba polyphaga'' minivirus<br />
-
[[2cyb]] – AfTyrRS + Tyr - ''Archaeoglobus fulgidus''<br />
+
**[[2dlc]] – yTyrRS + tRNA + Tyr-SA<br />
-
[[2cyc]] – PhTyrRS + Tyr<br />
+
**[[2cyb]] – AfTyrRS + Tyr - ''Archaeoglobus fulgidus''<br />
-
[[1q11]] – hTyrRS residues 1-364 + Tyr-ol<br />
+
**[[2cyc]] – PhTyrRS + Tyr<br />
-
[[1h3e]] - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP<br />
+
**[[1q11]] – hTyrRS residues 1-364 + Tyr-ol<br />
-
[[1h3f]] - TtTyrRS + Tyr-ol<br />
+
**[[1h3e]] - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP<br />
-
[[1jh3]] – GsTyrRS C-terminal – NMR<br />
+
**[[1h3f]] - TtTyrRS + Tyr-ol<br />
-
[[1jii]], [[ 1jij]], [[1jil]], [[1jik]] – SaTyrRS + inhibitor
+
**[[1jh3]] – GsTyrRS C-terminal – NMR<br />
 +
**[[1jii]], [[ 1jij]], [[1jil]], [[1jik]] – SaTyrRS + inhibitor
-
''Tyr-RS + tRNA''<br />
+
*''Tyr-RS + tRNA''<br />
-
[[1j1u]] – MjTyrRS + Tyr-tRNA
+
**[[1j1u]] – MjTyrRS + Tyr-tRNA
-
[[2rkj]] – NcTyrRS + RNA
+
**[[2rkj]] – NcTyrRS + RNA
-
===Val-RS===
+
*Val-RS
-
[[1iyw]] - TtValRS<br />
+
**[[1iyw]] - TtValRS<br />
-
[[1wk9]], [[ 1wka]] – TtValRS CP1 domain
+
**[[1wk9]], [[ 1wka]] – TtValRS CP1 domain
-
''Val-RS ternary complex''<br />
+
*''Val-RS ternary complex''<br />
-
[[1ivs]] – TtValRS + Val-SA + Val-tRNA<br />
+
**[[1ivs]] – TtValRS + Val-SA + Val-tRNA<br />
-
[[1gax]] - TtValRS + Val-adenylate analog + Val-tRNA
+
**[[1gax]] - TtValRS + Val-adenylate analog + Val-tRNA
-
===Class II aaRS===
+
*'''Class II aaRS'''
-
===Ala-RS===
+
*Ala-RS
-
[[3g98]] – AaAlaRS residues 758-867<br />
+
**[[3g98]] – AaAlaRS residues 758-867<br />
-
[[1riq]] - AaAlaRS catalytic fragment<br />
+
**[[1riq]] - AaAlaRS catalytic fragment<br />
-
[[2zze]], [[ 2zzf]], [[ 1wnu]], [[ 1wxo]], [[ 1v4p]] – PhAlaRS<br />
+
**[[2zze]], [[ 2zzf]], [[ 1wnu]], [[ 1wxo]], [[ 1v4p]] – PhAlaRS<br />
-
[[2zvf]] – AfAlaRS C-terminal
+
**[[2zvf]] – AfAlaRS C-terminal
-
''Ala-RS + small substrates or analogs''<br />
+
*''Ala-RS + small substrates or analogs''<br />
-
[[3hxu]], [[ 3hxv]], [[ 3hxw]] – EcAlaRS catalytic fragment + aa-adenylate <br />
+
**[[3hxu]], [[3hxv]], [[3hxw]] – EcAlaRS catalytic fragment + aa-adenylate <br />
-
[[3hxz]], [[ 3hy0]], [[ 3hy1]] - EcAlaRS catalytic fragment (mutant) + aa-adenylate<br />
+
**[[3hxz]], [[3hy0]], [[3hy1]] - EcAlaRS catalytic fragment (mutant) + aa-adenylate<br />
-
[[3hxx]] - EcAlaRS catalytic fragment + AMPPCP<br />
+
**[[3hxx]] - EcAlaRS catalytic fragment + AMPPCP<br />
-
[[3hxy]] - EcAlaRS catalytic fragment + AMPPCP + Ala-AMP + PCP<br />
+
**[[3hxy]] - EcAlaRS catalytic fragment + AMPPCP + Ala-AMP + PCP<br />
-
[[3htz]] - AaAlaRS residues 2-454 + Ser<br />
+
**[[3htz]] - AaAlaRS residues 2-454 + Ser<br />
-
[[1yfr]] – AaAlaRS + ATP<br />
+
**[[1yfr]] – AaAlaRS + ATP<br />
-
[[1yfs]] – AaAlaRS + Ala<br />
+
**[[1yfs]] – AaAlaRS + Ala<br />
-
[[1yft]], [[ 1ygb]] - AaAlaRS catalytic fragment + aa<br />
+
**[[1yft]], [[1ygb]] - AaAlaRS catalytic fragment + aa<br />
-
[[2zzg]] - PhAlaRS + Ala-SA<br />
+
**[[2zzg]] - PhAlaRS + Ala-SA<br /
-
[[2ztg]] – AfAlaRS + Ala-SA<br />
+
**[[2ztg]] – AfAlaRS + Ala-SA<br />
-
===Asp-RS===
+
*Asp-RS
-
[[3nen]], [[ 1b8a]] – TkAspRS - ''Thermococcus kodakarensis''<br />
+
**[[3nen]], [[1b8a]] – TkAspRS - ''Thermococcus kodakarensis''<br />
-
[[3i7f]] – EhAspRS<br />
+
**[[3i7f]] – EhAspRS<br />
-
[[1wyd]]– AspRS – ''Sulfolobus tokodaii''<br />
+
**[[1wyd]] – AspRS – ''Sulfolobus tokodaii''<br />
-
[[1eov]] - yAspRS<br />
+
**[[1eov]] - yAspRS<br />
-
[[1n9w]], [[ 1l0w]], [[ 1g51]] – TtAspRS<br />
+
[[1n9w]], [[1l0w]], [[1g51]] – TtAspRS<br />
-
[[1eqr]] – EcAspRS
+
**[[1eqr]] – EcAspRS
-
''Asp-RS + small substrates or analogs''<br />
+
*''Asp-RS + small substrates or analogs''<br />
-
[[3nel]] – TkAspRS + Asp <br />
+
**[[3nel]] – TkAspRS + Asp <br />
-
[[3nem]] - TkAspRS + Asp-adenylate
+
**[[3nem]] - TkAspRS + Asp-adenylate
-
''Asp-RS + tRNA''<br />
+
*''Asp-RS + tRNA''<br />
-
[[3kfu]], [[ 1efw]] – TtAspRS + tRNA <br />
+
**[[3kfu]], [[1efw]] – TtAspRS + tRNA <br />
-
[[1asy]], [[ 1asz]] – yAspRS + Asp-tRNA
+
**[[1asy]], [[1asz]] – yAspRS + Asp-tRNA
-
''Asp-RS ternary complex''<br />
+
*''Asp-RS ternary complex''<br />
-
[[1il2]], [[ 1c0a]] – EcAspRS + Asp-tRNA + Asp-adenylate
+
**[[1il2]], [[1c0a]] – EcAspRS + Asp-tRNA + Asp-adenylate
-
===Asn-RS===
+
*Asn-RS
-
[[1x56]] - PhAsnRS <br />
+
**[[1x56]] - PhAsnRS <br />
-
[[2kqr]] – BmAsnRS N-terminal – NMR – ''Brugia malayi''
+
**[[2kqr]] – BmAsnRS N-terminal – NMR – ''Brugia malayi''
-
''Asn-RS + small substrates or analogs''<br />
+
*''Asn-RS + small substrates or analogs''<br />
-
[[2xti]] – BmAsnRS catalytic fragment + Asn-adenine analog<br />
+
**[[2xti]] – BmAsnRS catalytic fragment + Asn-adenine analog<br />
-
[[2xgt]] - BmAsnRS catalytic fragment + Asn-SA<br />
+
**[[2xgt]] - BmAsnRS catalytic fragment + Asn-SA<br />
-
[[1x54]] – PhAsnRS + Asn-adenylate<br />
+
**[[1x54]] – PhAsnRS + Asn-adenylate<br />
-
[[1x55]] - PhAsnRS + Asn-SA<br />
+
**[[1x55]] - PhAsnRS + Asn-SA<br />
-
[[11as]] – EcAsnRS + Asn<br />
+
**[[11as]] – EcAsnRS + Asn<br />
-
[[12as]] - EcAsnRS + Asn + AMP
+
**[[12as]] - EcAsnRS + Asn + AMP
-
===Gly-RS===
+
*Gly-RS
-
[[1ati]] – TtGlyRS<br />
+
**[[1ati]] – TtGlyRS<br />
-
[[2q5h]] – hGlyRS residues 55-739<br />
+
**[[2q5h]] – hGlyRS residues 55-739<br />
-
[[2q5i]] - hGlyRS residues 55-739 (mutant) <br />
+
**[[2q5i]] - hGlyRS residues 55-739 (mutant) <br />
-
[[2pme]] – hGlyRS<br />
+
**[[2pme]] – hGlyRS<br />
-
[[2pmf]] – hGlyRS (mutant) <br />
+
**[[2pmf]] – hGlyRS (mutant) <br />
-
[[1j5w]] – TmGlyRS α chain
+
**[[1j5w]] – TmGlyRS α chain
-
''Gly-RS + small substrates or analogs''<br />
+
*''Gly-RS + small substrates or analogs''<br />
-
[[2zt5]], [[ 2zxf]] – hGlyRS residues 55-739 + bis-adenosine tetraphosphate<br />
+
**[[2zt5]], [[ 2zxf]] – hGlyRS residues 55-739 + bis-adenosine tetraphosphate<br />
-
[[2zt6]] - hGlyRS residues 55-739 + AMPCPP<br />
+
**[[2zt6]] - hGlyRS residues 55-739 + AMPCPP<br />
-
[[2zt7]] - hGlyRS residues 55-739 + Gly + ATP<br />
+
**[[2zt7]] - hGlyRS residues 55-739 + Gly + ATP<br />
-
[[2zt8]] - hGlyRS residues 55-739 + Gly-AMP analog<br />
+
**[[2zt8]] - hGlyRS residues 55-739 + Gly-AMP analog<br />
-
[[1b76]] – TtGlyRS + ATP<br />
+
**[[1b76]] – TtGlyRS + ATP<br />
-
[[1ggm]] – TtGlyRS + Gly-adenylate
+
**[[1ggm]] – TtGlyRS + Gly-adenylate
-
===His-RS===
+
*His-RS
-
[[1htt]] - EcHisRS<br />
+
**[[3net]] – HisRS – Nostoc<br />
-
[[3net]] – HisRS – Nostoc<br />
+
**[[1h4v]] – TtHisRS<br />
-
[[1h4v]] – TtHisRS<br />
+
**[[1qe0]] – SaHisRS<br />
-
[[1qe0]] – SaHisRS<br />
+
**[[3hri]] – TbHisRS<br />
-
[[3hri]] – TbHisRS<br />
+
**[[1x59]] – hHisRS WHEP-TRS domain - NMR
-
[[1wu7]] – HisRS – ''Thermoplasma acidophilum''<br />
+
-
[[1x59]] – hHisRS WHEP-TRS domain - NMR
+
-
''His-RS + small substrates or analogs''<br />
+
*''His-RS + small substrates or analogs''<br />
-
[[3lc0]] – HisRS residues 45-478 + His – ''Trypanosoma cruzi''<br />
+
**[[3lc0]] – HisRS residues 45-478 + His – ''Trypanosoma cruzi''<br />
-
[[1adj]] – TtHisRS + His <br />
+
**[[1adj]] – TtHisRS + His <br />
-
[[3hrk]] - TbHisRS + His-adenylate<br />
+
**[[3hrk]] - TbHisRS + His-adenylate<br />
-
[[2el9]] - EcHisRS + His-SA<br />
+
**[[2el9]] - EcHisRS + His-SA<br />
-
[[1kmm]], [[ 1ady]] - EcHisRS + His-adenylate<br />
+
**[[1kmm]], [[1ady]] - EcHisRS + His-adenylate<br />
-
[[1kmn]] - EcHisRS + His-ol + ATP
+
**[[1kmn]] - EcHisRS + His-ol + ATP
-
===Phe-RS===
+
*Phe-RS
-
[[1pys]] – TtPheRS<br />
+
**[[1pys]] – TtPheRS<br />
-
[[3l4g]], [[ 3cmq]] – hPheRS<br />
+
**[[3l4g]], [[ 3cmq]] – hPheRS<br />
-
[[2cxi]] – PhPheRS β chain N-terminal<br />[[3ica]] – PheRS β chain – ''Porphyromonas gingivalis''
+
**[[2cxi]] – PhPheRS β chain N-terminal<br />[[3ica]] – PheRS β chain – ''Porphyromonas gingivalis''
-
''Phe-RS + small substrates or analogs''<br />
+
*''Phe-RS + small substrates or analogs''<br />
-
[[3pco]] – EcPheRS + phenylalanine+ AMP<br />
+
**[[3pco]] – EcPheRS + phenylalanine+ AMP<br />
-
[[3hfz]], [[ 2amc]] – TtPheRS α+β chains + Tyr<br />
+
**[[3hfz]], [[2amc]] – TtPheRS α+β chains + Tyr<br />
-
[[2akw]], [[ 1b70]] - TtPheRS α+β chains + Phe<br />
+
**[[2akw]], [[1b70]] - TtPheRS α+β chains + Phe<br />
-
[[1jjc]], [[ 1b7y]] - TtPheRS α+β chains + Phe-adenylate<br />
+
**[[1jjc]], [[1b7y]] - TtPheRS α+β chains + Phe-adenylate<br />
-
[[2aly]] - TtPheRS α+β chains + Phe-SA<br />
+
**[[2aly]] - TtPheRS α+β chains + Phe-SA<br />
-
[[2rhq]], [[ 2rhs]] – PheRS α+β chains (mutant) + inhibitor – ''Staphylococcus haemolyticus''
+
**[[2rhq]], [[2rhs]] – PheRS α+β chains (mutant) + inhibitor – ''Staphylococcus haemolyticus''
-
''Phe-RS + tRNA''<br />
+
*''Phe-RS + tRNA''<br />
-
[[1eiy]] - TtPheRS α+β chains + Phe-tRNA
+
**[[1eiy]] - TtPheRS α+β chains + Phe-tRNA
-
''Phe-RS ternary complex''
+
*''Phe-RS ternary complex''
-
[[2iy5]] - TtPheRS α+β chains + Phe-ol + Phe-tRNA
+
**[[2iy5]] - TtPheRS α+β chains + Phe-ol + Phe-tRNA
-
===Pro-RS===
+
*Pro-RS
-
[[1hc7]] – TtProRS<br />
+
**[[1hc7]] – TtProRS<br />
-
[[2i4l]] – RpProRS – ''Rhodopseudomonas palustris''<br />
+
**[[2i4l]] – RpProRS – ''Rhodopseudomonas palustris''<br />
-
[[1nj2]] - MtProRS – ''Methanothermobacter thermautotrophicus''<br />
+
**[[1nj2]] - MtProRS – ''Methanothermobacter thermautotrophicus''<br />
-
[[1nj8]] – MjProRS
+
**[[1nj8]] – MjProRS
-
''Pro-RS + small substrates or analogs''<br />
+
*''Pro-RS + small substrates or analogs''<br />
-
[[3ial]] – GlProRS residues 34-542 + Pro-adenylate<br />
+
**[[3ial]] – GlProRS residues 34-542 + Pro-adenylate<br />
-
[[2i4m]], [[ 2i4n]] – RpProRS + aa-SA<br />
+
**[[2i4m]], [[2i4n]] – RpProRS + aa-SA<br />
-
[[2i4o]] – RpProRS + ATP<br />
+
**[[2i4o]] – RpProRS + ATP<br />
-
[[2j3l]] – EfProRS + Pro-SA – ''Enterococcus faecalis''<br />
+
**[[2j3l]] – EfProRS + Pro-SA – ''Enterococcus faecalis''<br />
-
[[2j3m]] – EfProRS + Pro-ol + ATP<br />
+
**[[2j3m]] – EfProRS + Pro-ol + ATP<br />
-
[[1nj1]], [[ 1nj5]], [[ 1nj6]] – MtProRS + aa-SA<br />
+
**[[1nj1]], [[1nj5]], [[1nj6]] – MtProRS + aa-SA<br />
-
[[1h4t]] - TtProRS + Pro
+
**[[1h4t]] - TtProRS + Pro
-
''Pro-RS ternary complex''<br />
+
*''Pro-RS ternary complex''<br />
-
[[1h4q]] - TtProRS + Pro-tRNA + Pro-ol<br />
+
**[[1h4q]] - TtProRS + Pro-tRNA + Pro-ol<br />
-
[[1h4s]] - TtProRS + Pro-tRNA + Pro-SA<br />
+
**[[1h4s]] - TtProRS + Pro-tRNA + Pro-SA<br />
-
===Ser-RS===
+
*Ser-RS
-
[[3lsq]] – TbSerRS<br />
+
**[[3lsq]] – TbSerRS<br />
-
[[1sry]] - TtSerRS<br />
+
**[[1sry]] - TtSerRS<br />
-
[[3err]] – TtSerRS/dynein heavy chain<br />
+
**[[3err]] – TtSerRS/dynein heavy chain<br />
-
[[2zr3]] – PhSerRS<br />
+
**[[2zr3]] – PhSerRS<br />
-
[[2dq3]] – AaSerRS<br />
+
**[[2dq3]] – AaSerRS<br />
-
[[2du7]] – MjSerRS<br />
+
**[[2du7]] – MjSerRS<br />
-
[[2odr]] – SerRS – ''Methanococcus maripaludis''<br />
+
**[[2odr]] – SerRS – ''Methanococcus maripaludis''<br />
-
[[2cim]] – MbSerRS – ''Methanosarcina barkeri''<br />
+
**[[2cim]] – MbSerRS – ''Methanosarcina barkeri''<br />
-
[[1wle]] – SerRS – bovine
+
**[[1wle]] – SerRS – bovine
-
''Ser-RS + small substrates or analogs''<br />
+
*''Ser-RS + small substrates or analogs''<br />
-
[[2zr2]] – PhSerRS + ATP<br />
+
**[[2zr2]] – PhSerRS + ATP<br />
-
[[2dq0]] – PhSerRS + Ser-SA<br />
+
**[[2cj9]] – MbSerRS + Ser-SA<br />
-
[[2cj9]] – MbSerRS + Ser-SA<br />
+
**[[2cjb]] – MbSerRS + Ser<br />
-
[[2cjb]] – MbSerRS + Ser<br />
+
**[[2cja]] – MbSerRS + ATP<br />
-
[[2cja]] – MbSerRS + ATP<br />
+
**[[1ses]], [[1set]] – TtSerRS + Ser-adenylate analog<br />
-
[[1ses]], [[ 1set]] – TtSerRS + Ser-adenylate analog<br />
+
**[[3lss]] – TbSerRS + ATP
-
[[3lss]] – TbSerRS + ATP
+
-
''Ser-RS + tRNA''<br />
+
*''Ser-RS + tRNA''<br />
-
[[1ser]] – TtSerRS + Ser-tRNA<br />
+
**[[1ser]] – TtSerRS + Ser-tRNA<br />
-
[[2du4]] - AfSerRS + Cys-tRNA
+
**[[2du4]] - AfSerRS + Cys-tRNA
-
''Ser-RS ternary complex''<br />
+
*''Ser-RS ternary complex''<br />
-
[[2du3]] – AfSerRS + Cys-tRNA + phosphoserine<br />
+
**[[2du3]] – AfSerRS + Cys-tRNA + phosphoserine<br />
-
[[2du5]], [[ 2du6]] - AfSerRS (mutant) + Cys-tRNA + phosphoserine
+
**[[2du5]], [[2du6]] - AfSerRS (mutant) + Cys-tRNA + phosphoserine
-
===Thr-RS===
+
*Thr-RS
-
[[1y2q]] - PaThrRS editing domain<br />
+
**[[1y2q]] - PaThrRS editing domain<br />
-
[[1wwt]] – hThrRS TGS domain – NMR<br />
+
**[[1wwt]] – hThrRS TGS domain – NMR<br />
-
[[1tje]] - EcThrRS editing domain
+
**[[1tje]] - EcThrRS editing domain
-
''Thr-RS + small substrates or analogs''<br />
+
*''Thr-RS + small substrates or analogs''<br />
-
[[3pd2]], [[ 3pd3]], [[ 3pd4]], [[ 3pd5]] – PaThrRS editing domain + aa-aminoadenosine<br />
+
**[[3pd2]], [[3pd3]], [[3pd4]], [[3pd5]] – PaThrRS editing domain + aa-aminoadenosine<br />
-
[[2hkz]] – PaThrRS editing domain + Ser<br />
+
**[[2hkz]] – PaThrRS editing domain + Ser<br />
-
[[2hl0]], [[ 2hl1]] - PaThrRS editing domain + Ser-adenylate<br />
+
**[[2hl0]], [[2hl1]] - PaThrRS editing domain + Ser-adenylate<br />
-
[[2hl2]] - PaThrRS editing domain + Ser-SA<br />
+
**[[2hl2]] - PaThrRS editing domain + Ser-SA<br />
-
[[1tke]] - EcThrRS editing domain + Ser<br />
+
**[[1tke]] - EcThrRS editing domain + Ser<br />
-
[[1tkg]] - EcThrRS editing domain + Ser-SA<br />
+
**[[1tkg]] - EcThrRS editing domain + Ser-SA<br />
-
[[1tky]] - EcThrRS editing domain + Ser-adenylate<br />
+
**[[1tky]] - EcThrRS editing domain + Ser-adenylate<br />
-
[[1fyf]], [[ 1evl]] - EcThrRS catalytic and anticodon-binding domains + aa-SA<br />
+
**[[1fyf]], [[1evl]] - EcThrRS catalytic and anticodon-binding domains + aa-SA<br />
-
[[1evk]] - EcThrRS catalytic and anticodon-binding domains + Thr<br />
+
**[[1evk]] - EcThrRS catalytic and anticodon-binding domains + Thr<br />
-
[[1nyq]] – SaThrRS + Thr-SA<br />
+
**[[1nyq]] – SaThrRS + Thr-SA<br />
-
[[1nyr]] – SaThrRS + ATP
+
**[[1nyr]] – SaThrRS + ATP
-
''Thr-RS + tRNA''<br />
+
*''Thr-RS + tRNA''<br />
-
[[1qf6]] – EcThrRS + Thr-tRNA<br />
+
**[[1qf6]] – EcThrRS + Thr-tRNA<br />
-
[[1kog]] – EcThrRS catalytic and anticodon-binding domains + mRNA
+
**[[1kog]] – EcThrRS catalytic and anticodon-binding domains + mRNA
-
'''Multifunctional RS'''
+
*Multifunctional RS
-
 
+
-
[[1fyj]] – hRS - NMR
+
 +
**[[1fyj]] – hRS - NMR
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:57, 16 November 2014

Image:3l4g.png
Crystal Structure of Aminoacyl tRNA synthetase 3l4g

Template:STRUCTURE 1f7v














Aminoacyl tRNA synthetase (aaRS) catalyzes the esterification of a specific amino acid to its cognate tRNA to form an aminoacyl-tRNA. The amino acid is transferred by the ribosome from the aminoacylated-tRNA onto a growing polypeptide chain. Class I of aaRS is a monomer or dimer, it has 2 highly conserved sequence motifs and it aminoacylates at the 2’-OH of an adenosine nucleotide. Class II of aaRS is a dimer or tetramer, it has 3 highly conserved sequence motifs and it aminoacylates at the 3’-OH of an adenosine nucleotide. CP1 domain of RS edits a mischarged aa-tRNA. Some of the crystal structures are complexes of the RS with their reactant analog: amino acid-sulfamoyl adenine (aa-SA).


3D Structures of Aminoacyl tRNA synthetase

Updated on 16-November-2014

1n9w, 1l0w, 1g51 – TtAspRS

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Ann Taylor

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