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Aminopeptidase

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<StructureSection load='VH9.pdb' size='450' side='right' scene='Journal:JBIC:15/Cv/1' caption='Bacterial leucine aminopeptidase complex with 8-hydroxyquinoline, glycerol, SCN, Zn+2 (magenta), Na+ (cyan) and Cl- (green) ions (PDB code [[3vh9]])'>[[Aminopeptidase|Aminopeptidases]] (AP) ([[EC]] 3) are metal - mostly Zn-dependent enzymes involved in the digestion of proteins. Cytosol AP (Cyt-AP), deblocking AP (DAP) and AP N (APN) remove N-terminal amino acids. The AP are classified by the amino acid which they hydrolyze. Other types of AP are: Cold-activated AP (Col-AP), Heat stable AP from ''Thermus thermophilus'' (AmpT), AP from ''Staphylococcus aureus'' (AmpS) and SGAP from ''Stereomyces griseus''. Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide. See details of SGAP in [[Streptomyces griseus Aminopeptidase (SGAP)]]. Beta-peptidyl AP (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.
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<StructureSection load='VH9.pdb' size='450' side='right' scene='Journal:JBIC:15/Cv/1' caption='Bacterial leucine aminopeptidase complex with 8-hydroxyquinoline, glycerol, SCN, Zn+2 (magenta), Na+ (cyan) and Cl- (green) ions (PDB code [[3vh9]])'>[[Aminopeptidase|Aminopeptidases]] (AP) ([[EC]] 3) are metal - mostly Zn-dependent enzymes involved in the digestion of proteins. Cytosol AP (Cyt-AP), deblocking AP (DAP) and AP N (APN) remove N-terminal amino acids. The AP are classified by the amino acid which they hydrolyze. Other types of AP are:<br />
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* '''Cold-activated AP''' (Col-AP)<br />
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* '''Heat stable AP''' from ''Thermus thermophilus'' (AmpT)<br />
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* '''AP from ''Staphylococcus aureus''''' (AmpS)<br />
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* '''SGAP''' from ''Stereomyces griseus''. See details in [[Streptomyces griseus Aminopeptidase (SGAP)]].<br />
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* '''Alanine aminopeptidase''' is called '''aminopeptidase N'''. See details in [[Aminopeptidase N]].<br '>
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Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide. Beta-peptidyl AP (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.
== Aminopeptidase from ''Aeromonas proteolytica''<ref>DOI 10.1007/s00775-012-0873-4</ref> ==
== Aminopeptidase from ''Aeromonas proteolytica''<ref>DOI 10.1007/s00775-012-0873-4</ref> ==

Revision as of 09:20, 22 December 2014

Bacterial leucine aminopeptidase complex with 8-hydroxyquinoline, glycerol, SCN, Zn+2 (magenta), Na+ (cyan) and Cl- (green) ions (PDB code 3vh9)

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3D Structures of Aminopeptidase

Updated on 22-December-2014

Additional Resources

For additional information, see:
Amino Acid Synthesis & Metabolism
Streptomyces griseus Aminopeptidase (SGAP)

References

  1. ↑ Hanaya K, Suetsugu M, Saijo S, Yamato I, Aoki S. Potent inhibition of dinuclear zinc(II) peptidase, an aminopeptidase from Aeromonas proteolytica, by 8-quinolinol derivatives: inhibitor design based on Zn(2+) fluorophores, kinetic, and X-ray crystallographic study. J Biol Inorg Chem. 2012 Feb 5. PMID:22311113 doi:10.1007/s00775-012-0873-4

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