Androgen receptor
From Proteopedia
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**[[1i37]] – rAR + DHT <br /> | **[[1i37]] – rAR + DHT <br /> | ||
**[[1i38]] – rAR (mutant) + DHT <br /> | **[[1i38]] – rAR (mutant) + DHT <br /> | ||
| - | **[[2ama]] – hAR + DHT - human<br /> | + | **[[2ama]], [[4oea]] – hAR + DHT - human<br /> |
**[[1t7t]] – cAR + DHT - chimpanzee<br /> | **[[1t7t]] – cAR + DHT - chimpanzee<br /> | ||
**[[2ylo]], [[2ylp]], [[2ylq]], [[3zqt]], [[4hlw]] – hAR + testosterone + benzoate derivative<br /> | **[[2ylo]], [[2ylp]], [[2ylq]], [[3zqt]], [[4hlw]] – hAR + testosterone + benzoate derivative<br /> | ||
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**[[1gs4]] – hAR (mutant) + corticosteroid<br /> | **[[1gs4]] – hAR (mutant) + corticosteroid<br /> | ||
**[[1z95]], [[3rlj]] – hAR + anti-androgen <br /> | **[[1z95]], [[3rlj]] – hAR + anti-androgen <br /> | ||
| - | **[[2oz7]], [[3rll]] – hAR (mutant) + anti-androgen <br /> | + | **[[2oz7]], [[3rll]], [[4ogh]], [[4ojb]] – hAR (mutant) + anti-androgen <br /> |
**[[2ax6]], [[2ax7]], [[2ax8]] – hAR (mutant) + nonsteroidal ligand <br /> | **[[2ax6]], [[2ax7]], [[2ax8]] – hAR (mutant) + nonsteroidal ligand <br /> | ||
**[[2ax9]], [[2axa]] – hAR + nonsteroidal ligand <br /> | **[[2ax9]], [[2axa]] – hAR + nonsteroidal ligand <br /> | ||
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**[[2ihq]], [[2nw4]], [[3g0w]] – rAR + modulator <br /> | **[[2ihq]], [[2nw4]], [[3g0w]] – rAR + modulator <br /> | ||
**[[2hvc]], [[3b5r]], [[3b65]], [[3b66]], [[3b67]], [[3b68]] – hAR + modulator <br /> | **[[2hvc]], [[3b5r]], [[3b65]], [[3b66]], [[3b67]], [[3b68]] – hAR + modulator <br /> | ||
| + | **[[4k7a]] – hAR + hair growth drug <br /> | ||
*''AR LBD domain complex with peptide'' | *''AR LBD domain complex with peptide'' | ||
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**[[1t63]], [[1t65]] – hAR + DHT + nuclear receptor coactivator 2 peptide<br /> | **[[1t63]], [[1t65]] – hAR + DHT + nuclear receptor coactivator 2 peptide<br /> | ||
**[[3l3x]], [[3l3z]] – hAR + DHT + nuclear receptor coactivator 3 peptide<br /> | **[[3l3x]], [[3l3z]] – hAR + DHT + nuclear receptor coactivator 3 peptide<br /> | ||
| + | **[[4oed]], [[4oey]], [[4oez]], [[4ofr]], [[4ofu]] – hAR (mutant) + DHT + co-regulator peptide <br /> | ||
| + | **[[4oh5]], [[4oh6]], [[4oha]], [[4oil]], [[4oiu]], [[4oj9]], [[4ok1]], [[4okb]], [[4okt]], [[4okw]], [[4okx]], [[4olm]] – hAR (mutant) + antiandrogen + co-regulator peptide <br /> | ||
**[[2z4j]] – hAR + DHT + nuclear receptor 0B2 peptide<br /> | **[[2z4j]] – hAR + DHT + nuclear receptor 0B2 peptide<br /> | ||
**[[2q7j]] – hAR + testosterone + nuclear receptor coactivator 2 peptide<br /> | **[[2q7j]] – hAR + testosterone + nuclear receptor coactivator 2 peptide<br /> | ||
Revision as of 12:20, 29 January 2015
Androgen receptor (AR) is a nuclear receptor which is activated by testosterone or 5-α-dihydrotestosterone (DHT) hormone. Upon binding the androgenic hormone it translocates to the nucleus where it acts as a DNA-binding transcription factor. The AR binds to a specific sequence of DNA called hormone response element. AR binds to other proteins in the nucleus causing up- or down gene regulation. AR exists in two isoforms. AR-B is full length 110 kDa and AR-A (87 kDa) lacks the N-terminal 187 amino acids. AR structure is composed of 5 domains -
A/B: N-terminal contains the activation functions and dimerization surface
C: DNA binding domain (DBD)
D: Hinge region between DBD and LBD
E: Ligand binding domain (LBD) which binds the N-terminal FXXFL motif
F: C-terminal domain
3D Structures of androgen receptor
Updated on 29-January-2015
See Also
Proteopedia Page Contributors and Editors (what is this?)
Cristina Benito, Michal Harel, Cristina Murga, Marta Roldan Lazaro, Alexander Berchansky, Joel L. Sussman, Wayne Decatur, David Sánchez Fernández
