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Androgen receptor

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Line 25: Line 25:
**[[1i37]] – rAR + DHT <br />
**[[1i37]] – rAR + DHT <br />
**[[1i38]] – rAR (mutant) + DHT <br />
**[[1i38]] – rAR (mutant) + DHT <br />
-
**[[2ama]] – hAR + DHT - human<br />
+
**[[2ama]], [[4oea]] – hAR + DHT - human<br />
**[[1t7t]] – cAR + DHT - chimpanzee<br />
**[[1t7t]] – cAR + DHT - chimpanzee<br />
**[[2ylo]], [[2ylp]], [[2ylq]], [[3zqt]], [[4hlw]] – hAR + testosterone + benzoate derivative<br />
**[[2ylo]], [[2ylp]], [[2ylq]], [[3zqt]], [[4hlw]] – hAR + testosterone + benzoate derivative<br />
Line 37: Line 37:
**[[1gs4]] – hAR (mutant) + corticosteroid<br />
**[[1gs4]] – hAR (mutant) + corticosteroid<br />
**[[1z95]], [[3rlj]] – hAR + anti-androgen <br />
**[[1z95]], [[3rlj]] – hAR + anti-androgen <br />
-
**[[2oz7]], [[3rll]] – hAR (mutant) + anti-androgen <br />
+
**[[2oz7]], [[3rll]], [[4ogh]], [[4ojb]] – hAR (mutant) + anti-androgen <br />
**[[2ax6]], [[2ax7]], [[2ax8]] – hAR (mutant) + nonsteroidal ligand <br />
**[[2ax6]], [[2ax7]], [[2ax8]] – hAR (mutant) + nonsteroidal ligand <br />
**[[2ax9]], [[2axa]] – hAR + nonsteroidal ligand <br />
**[[2ax9]], [[2axa]] – hAR + nonsteroidal ligand <br />
Line 44: Line 44:
**[[2ihq]], [[2nw4]], [[3g0w]] – rAR + modulator <br />
**[[2ihq]], [[2nw4]], [[3g0w]] – rAR + modulator <br />
**[[2hvc]], [[3b5r]], [[3b65]], [[3b66]], [[3b67]], [[3b68]] – hAR + modulator <br />
**[[2hvc]], [[3b5r]], [[3b65]], [[3b66]], [[3b67]], [[3b68]] – hAR + modulator <br />
 +
**[[4k7a]] – hAR + hair growth drug <br />
*''AR LBD domain complex with peptide''
*''AR LBD domain complex with peptide''
Line 53: Line 54:
**[[1t63]], [[1t65]] – hAR + DHT + nuclear receptor coactivator 2 peptide<br />
**[[1t63]], [[1t65]] – hAR + DHT + nuclear receptor coactivator 2 peptide<br />
**[[3l3x]], [[3l3z]] – hAR + DHT + nuclear receptor coactivator 3 peptide<br />
**[[3l3x]], [[3l3z]] – hAR + DHT + nuclear receptor coactivator 3 peptide<br />
 +
**[[4oed]], [[4oey]], [[4oez]], [[4ofr]], [[4ofu]] – hAR (mutant) + DHT + co-regulator peptide <br />
 +
**[[4oh5]], [[4oh6]], [[4oha]], [[4oil]], [[4oiu]], [[4oj9]], [[4ok1]], [[4okb]], [[4okt]], [[4okw]], [[4okx]], [[4olm]] – hAR (mutant) + antiandrogen + co-regulator peptide <br />
**[[2z4j]] – hAR + DHT + nuclear receptor 0B2 peptide<br />
**[[2z4j]] – hAR + DHT + nuclear receptor 0B2 peptide<br />
**[[2q7j]] – hAR + testosterone + nuclear receptor coactivator 2 peptide<br />
**[[2q7j]] – hAR + testosterone + nuclear receptor coactivator 2 peptide<br />

Revision as of 12:20, 29 January 2015


Template:STRUCTURE 2q7i

Androgen receptor (AR) is a nuclear receptor which is activated by testosterone or 5-α-dihydrotestosterone (DHT) hormone. Upon binding the androgenic hormone it translocates to the nucleus where it acts as a DNA-binding transcription factor. The AR binds to a specific sequence of DNA called hormone response element. AR binds to other proteins in the nucleus causing up- or down gene regulation. AR exists in two isoforms. AR-B is full length 110 kDa and AR-A (87 kDa) lacks the N-terminal 187 amino acids. AR structure is composed of 5 domains -
A/B: N-terminal contains the activation functions and dimerization surface
C: DNA binding domain (DBD)
D: Hinge region between DBD and LBD
E: Ligand binding domain (LBD) which binds the N-terminal FXXFL motif
F: C-terminal domain

3D Structures of androgen receptor

Updated on 29-January-2015

See Also

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