1g44

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WARNING: This structure was flagged as problematic. For additional information see '''2009, December:''' at [[Retractions and Fraud]].</td></tr></table>==CRYSTAL STRUCTURE OF A COMPLEMENT CONTROL PROTEIN THAT REGULATES BOTH PATHWAYS OF COMPLEMENT ACTIVATION AND BINDS HEPARAN SULFATE PROTEOGLYCANS==
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[[Image:1g44.png|left|200px]]
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<StructureSection load='1g44' size='340' side='right' caption='[[1g44]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1g44]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G44 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1g44 RCSB], [http://www.ebi.ac.uk/pdbsum/1g44 PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/1g44_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Vaccinia virus complement control protein (VCP) inhibits both pathways of complement activation through binding the third and fourth components. A homolog of mammalian regulators of complement activation, its ability to bind heparin endows VCP with additional activities of significance to viral infectivity. The structure of VCP reveals a highly extended molecule with a putative heparin recognition site at its C-terminal end. A second cluster of positive charges provides a possibly overlapping binding site for both heparin and complement components. Experiments suggested by the structure indicate that VCP can bind heparin and control complement simultaneously. This, the structure of any intact regulator of complement activation, along with attendant functional insights, will stimulate the design of new therapeutic inhibitors of complement.
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Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans.,Murthy KH, Smith SA, Ganesh VK, Judge KW, Mullin N, Barlow PN, Ogata CM, Kotwal GJ Cell. 2001 Jan 26;104(2):301-11. PMID:11207370<ref>PMID:11207370</ref>
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The line below this paragraph, containing "STRUCTURE_1g44", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_1g44| PDB=1g44 | SCENE= }}
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===CRYSTAL STRUCTURE OF A COMPLEMENT CONTROL PROTEIN THAT REGULATES BOTH PATHWAYS OF COMPLEMENT ACTIVATION AND BINDS HEPARAN SULFATE PROTEOGLYCANS===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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*[[Retractions and Fraud|Retractions and Fraud]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11207370}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 11207370 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_11207370}}
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</StructureSection>
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==About this Structure==
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1G44 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G44 OCA].
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==Reference==
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<ref group="xtra">PMID:11207370</ref><references group="xtra"/>
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[[Category: Vaccinia virus]]
[[Category: Vaccinia virus]]
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[[Category: Barlow, P N.]]
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[[Category: Barlow, P N]]
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[[Category: Ganesh, V K.]]
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[[Category: Ganesh, V K]]
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[[Category: Judge, K W.]]
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[[Category: Judge, K W]]
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[[Category: Kotwal, G J.]]
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[[Category: Kotwal, G J]]
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[[Category: Mullin, N.]]
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[[Category: Mullin, N]]
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[[Category: Murthy, K H.M.]]
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[[Category: Murthy, K H.M]]
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[[Category: Ogata, C M.]]
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[[Category: Ogata, C M]]
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[[Category: Smith, S A.]]
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[[Category: Smith, S A]]
[[Category: Beta]]
[[Category: Beta]]
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[[Category: Immune system]]
[[Category: Module]]
[[Category: Module]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:37:32 2009''
 

Revision as of 08:00, 18 November 2014

WARNING: This structure was flagged as problematic. For additional information see 2009, December: at Retractions and Fraud.
==CRYSTAL STRUCTURE OF A COMPLEMENT CONTROL PROTEIN THAT REGULATES BOTH PATHWAYS OF COMPLEMENT ACTIVATION AND BINDS HEPARAN SULFATE PROTEOGLYCANS==

1g44, resolution 2.60Å

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Proteopedia Page Contributors and Editors (what is this?)

OCA, Eric Martz

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