1rid

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m (Protected "1rid" [edit=sysop:move=sysop])
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<table cellpadding='5'><tr><td style='background-color: yellow;border:2px solid black;font-size:150%;'>
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WARNING: This structure was flagged as problematic. For additional information see '''2009, December:''' at [[Retractions and Fraud]].</td></tr></table>
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[[Image:1rid.png|left|200px]]
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==Vaccinia Complement Protein in Complex with Heparin==
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<StructureSection load='1rid' size='340' side='right' caption='[[1rid]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rid]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RID FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g40|1g40]], [[1g44|1g44]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C3L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10245 Vaccinia virus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rid RCSB], [http://www.ebi.ac.uk/pdbsum/1rid PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/1rid_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Vaccinia virus complement control protein (VCP), a homolog of the regulators of the complement activation family of proteins, inhibits complement activation through mechanisms similar to human fluid-phase complement regulators factor H and C4b-binding protein. VCP has a heparin-binding activity that assists vaccinia in host interactions. Interaction with cell-surface polyanions like heparin is centrally important in the functioning of fluid-phase complement regulators and is the basis of host-target discrimination by the alternative pathway. We report the structure of VCP in complex with a heparin decasaccharide, which reveals changes in VCP that might be pertinent to complement regulation. Properties that VCP shares with fluid-phase complement regulators suggest that such conformational changes may be of relevance in the functioning of other complement regulators. Additionally, comparison of VCP-heparin interactions with potentially similar interactions in factor H might enable understanding of the structural basis of familial hemolytic uremic syndrome, attributed to mutational disruption of heparin and C3b binding by factor H.
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Structure of vaccinia complement protein in complex with heparin and potential implications for complement regulation.,Ganesh VK, Smith SA, Kotwal GJ, Murthy KH Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8924-9. Epub 2004 Jun 3. PMID:15178763<ref>PMID:15178763</ref>
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The line below this paragraph, containing "STRUCTURE_1rid", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_1rid| PDB=1rid | SCENE= }}
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===Vaccinia Complement Protein in Complex with Heparin===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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*[[Retractions and Fraud|Retractions and Fraud]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15178763}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 15178763 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_15178763}}
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</StructureSection>
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==About this Structure==
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1RID is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RID OCA].
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==Reference==
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<ref group="xtra">PMID:15178763</ref><references group="xtra"/>
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[[Category: Vaccinia virus]]
[[Category: Vaccinia virus]]
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[[Category: Ganesh, V K.]]
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[[Category: Ganesh, V K]]
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[[Category: Kotwal, G J.]]
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[[Category: Kotwal, G J]]
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[[Category: Murthy, K H.M.]]
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[[Category: Murthy, K H.M]]
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[[Category: Smith, S A.]]
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[[Category: Smith, S A]]
[[Category: Complement]]
[[Category: Complement]]
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[[Category: Immune system]]
[[Category: Regulation]]
[[Category: Regulation]]
[[Category: Scr]]
[[Category: Scr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:55:43 2009''
 

Revision as of 08:29, 18 November 2014

WARNING: This structure was flagged as problematic. For additional information see 2009, December: at Retractions and Fraud.

Vaccinia Complement Protein in Complex with Heparin

1rid, resolution 2.10Å

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Proteopedia Page Contributors and Editors (what is this?)

OCA, Eric Martz

Retrieved from "http://52.214.119.220/wiki/index.php/1rid"
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