2etf
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2etf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2etf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2etf RCSB], [http://www.ebi.ac.uk/pdbsum/2etf PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2etf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2etf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2etf RCSB], [http://www.ebi.ac.uk/pdbsum/2etf PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 16:48, 24 December 2014
Crystal structure of full length botulinum neurotoxin (Type B) light chain
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