1l8r
From Proteopedia
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|PDB= 1l8r |SIZE=350|CAPTION= <scene name='initialview01'>1l8r</scene>, resolution 1.65Å | |PDB= 1l8r |SIZE=350|CAPTION= <scene name='initialview01'>1l8r</scene>, resolution 1.65Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8r OCA], [http://www.ebi.ac.uk/pdbsum/1l8r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l8r RCSB]</span> | ||
}} | }} | ||
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[[Category: winged-helix]] | [[Category: winged-helix]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:59:40 2008'' |
Revision as of 18:59, 30 March 2008
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| , resolution 1.65Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the Retinal Determination Protein Dachshund Reveals a DNA-Binding Motif
Overview
The Dachshund proteins are essential components of a regulatory network controlling cell fate determination. They have been implicated in eye, limb, brain, and muscle development. These proteins cannot be assigned to any recognizable structural or functional class based on amino acid sequence analysis. The 1.65 A crystal structure of the most conserved domain of human DACHSHUND is reported here. The protein forms an alpha/beta structure containing a DNA binding motif similar to that found in the winged helix/forkhead subgroup of the helix-turn-helix family. This unexpected finding alters the previously proposed molecular models for the role of Dachshund in the eye determination pathway. Furthermore, it provides a rational framework for future mechanistic analyses of the Dachshund proteins in several developmental contexts.
About this Structure
1L8R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the retinal determination protein Dachshund reveals a DNA binding motif., Kim SS, Zhang RG, Braunstein SE, Joachimiak A, Cvekl A, Hegde RS, Structure. 2002 Jun;10(6):787-95. PMID:12057194
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