Caspase
From Proteopedia
(Difference between revisions)
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**[[2xyg]], [[2xyh]], [[2xyp]], [[4jje]] – hCASP subunits P12, P17 + inhibitor<br /> | **[[2xyg]], [[2xyh]], [[2xyp]], [[4jje]] – hCASP subunits P12, P17 + inhibitor<br /> | ||
**[[2xzd]], [[2xzt]], [[2y0b]] - hCASP subunits P12, P17 + DARPIN-3.4<br /> | **[[2xzd]], [[2xzt]], [[2y0b]] - hCASP subunits P12, P17 + DARPIN-3.4<br /> | ||
| - | **[[3pcx]], [[3pd1]], [[3pd0]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3edq]], [[3edr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2cdr]], [[2h65]], [[1cp3]], [[1pau]] – hCASP + polypeptide inhibitor<br /> | + | **[[3pcx]], [[3pd1]], [[3pd0]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3edq]], [[3edr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2cdr]], [[2h65]], [[1cp3]], [[1pau]], [[4pry]] – hCASP + polypeptide inhibitor<br /> |
| - | **[[4dcj]], [[4dco]], [[4dcp]], [[4eha]], [[4ehd]], [[4ehf]], [[4ehh]], [[4ehk]], [[4ehl]], [[4ehn]] – hCASP subunits P12, P17 + polypeptide inhibitor<br /> | + | **[[4dcj]], [[4dco]], [[4dcp]], [[4eha]], [[4ehd]], [[4ehf]], [[4ehh]], [[4ehk]], [[4ehl]], [[4ehn]], [[4ps0]], [[4ps1]] – hCASP subunits P12, P17 + polypeptide inhibitor<br /> |
| - | **[[2dko]], [[2cjx]], [[2cjy]] - hCASP (mutant) + polypeptide inhibitor<br /> | + | **[[2dko]], [[2cjx]], [[2cjy]], [[4qtx]], [[4qty]], [[4qu0]], [[4qu5]], [[4qu8]], [[4qu9]], [[4qua]], [[4qub]] [[4qud]], [[4que]], [[4qug]], [[4quh]], [[4qui]], [[4quj]], [[4qul]] - hCASP (mutant) + polypeptide inhibitor<br /> |
**[[3kjf]], [[3h0e]], [[3deh]], [[3dei]], [[3dej]], [[3dek]], [[1re1]], [[1rhj]], [[1rhk]], [[1rhm]], [[1rhq]], [[1rhr]], [[1rhu]], [[1nme]], [[1nmq]], [[1nms]], [[1gfw]] – hCASP + inhibitor<br /> | **[[3kjf]], [[3h0e]], [[3deh]], [[3dei]], [[3dej]], [[3dek]], [[1re1]], [[1rhj]], [[1rhk]], [[1rhm]], [[1rhq]], [[1rhr]], [[1rhu]], [[1nme]], [[1nmq]], [[1nms]], [[1gfw]] – hCASP + inhibitor<br /> | ||
**[[3itn]], [[2j30]], [[2j31]], [[2j32]], [[2j33]], [[2c1e]], [[2c2k]], [[2c2m]], [[2c2o]], [[2c2z]], [[2h5i]], [[2h5j]], [[4jr0]] – hpro-CASP + polypeptide inhibitor<br /> | **[[3itn]], [[2j30]], [[2j31]], [[2j32]], [[2j33]], [[2c1e]], [[2c2k]], [[2c2m]], [[2c2o]], [[2c2z]], [[2h5i]], [[2h5j]], [[4jr0]] – hpro-CASP + polypeptide inhibitor<br /> | ||
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**[[1k88]] – hpro-CASP (mutant) <br /> | **[[1k88]] – hpro-CASP (mutant) <br /> | ||
**[[3ibc]], [[2ql5]], [[2ql7]], [[2ql9]], [[2qlb]], [[2qlf]], [[2qlj]], [[3edr]] - hCASP P20 subunit + polypeptide inhibitor<br /> | **[[3ibc]], [[2ql5]], [[2ql7]], [[2ql9]], [[2qlb]], [[2qlf]], [[2qlj]], [[3edr]] - hCASP P20 subunit + polypeptide inhibitor<br /> | ||
| - | **[[1f1j]] - hCASP + polypeptide inhibitor<br /> | + | **[[1f1j]], [[4hqr]] - hCASP + polypeptide inhibitor<br /> |
**[[3h1p]], [[4jr1]], [[4jr2]] - hCASP catalytic domain (mutant) + polypeptide inhibitor<br /> | **[[3h1p]], [[4jr1]], [[4jr2]] - hCASP catalytic domain (mutant) + polypeptide inhibitor<br /> | ||
**[[1shj]], [[1shl]] - hCASP catalytic domain (mutant) + inhibitor<br /> | **[[1shj]], [[1shl]] - hCASP catalytic domain (mutant) + inhibitor<br /> | ||
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**[[1i51]], [[1kmc]] - hCASP (mutant) + XIAP-BIR2<br /> | **[[1i51]], [[1kmc]] - hCASP (mutant) + XIAP-BIR2<br /> | ||
**[[1i4o]] - hCASP P20 subunit + XIAP<br /> | **[[1i4o]] - hCASP P20 subunit + XIAP<br /> | ||
| - | **[[4jb8]] - hCASP P20, P11 subunits + DARPIN<br /> | + | **[[4jb8]], [[4lsz]] - hCASP P20, P11 subunits + DARPIN<br /> |
*CASP-8 | *CASP-8 | ||
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**[[3kjn]], [[3kjq]] – hCASP subunit P18 + inhibitor<br /> | **[[3kjn]], [[3kjq]] – hCASP subunit P18 + inhibitor<br /> | ||
**[[1f9e]], [[1qtn]], [[1qdu]] - hCASP subunit α,β + polypeptide inhibitor<br /> | **[[1f9e]], [[1qtn]], [[1qdu]] - hCASP subunit α,β + polypeptide inhibitor<br /> | ||
| - | **[[1qtn]], [[4jj7]], [[4jj8]] - hCASP P18, P11 + polypeptide inhibitor<br /> | + | **[[1qtn]], [[4jj7]], [[4jj8]], [[4prz]] - hCASP P18, P11 + polypeptide inhibitor<br /> |
**[[3h11]] - hCASP (mutant) + polypeptide inhibitor<br /> | **[[3h11]] - hCASP (mutant) + polypeptide inhibitor<br /> | ||
**[[2y1l]] - hCASP subunits P18 P10<br /> | **[[2y1l]] - hCASP subunits P18 P10<br /> | ||
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**[[3v3k]] – hCASP + effector protein<br /> | **[[3v3k]] – hCASP + effector protein<br /> | ||
**[[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br /> | **[[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br /> | ||
| - | **[[3ygs]] – hpro-CASP + APAF-1 CARD | + | **[[3ygs]], [[4rhw]] – hpro-CASP + APAF-1 CARD |
*''Drosophila melanogaster'' CASP | *''Drosophila melanogaster'' CASP | ||
Revision as of 10:50, 11 March 2015
Template:STRUCTURE 1pyo
Caspase (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP.
- CASP-1 (or Interleukin-1 beta converting enzyme, ICE) cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein.
- CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis.
- CASP-7 is a heterodimer consisting of P20 (human residues 1-198) and P11 (human residues 199-303) subunits. CASP-7 catalytic domain consists of residues 57-303. is an important initiator CASP and drICE is an effector of apoptosis CASP in Drosophila melanogaster.
- Metacaspase (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi.
For some details see:
CASP-1 - Human Caspase-1
CASP-3 - Sandox Bay Serrano;
CASP-6 - Molecular Playground/Caspase-6 (new);
CASP-7 - Molecular Playground/Caspase-7 Dynamics
CASP-9 - Molecular Playground/Caspase-9 Regulation.
3D structures of caspase
Updated on 11-March-2015
