Catabolite gene activator protein
From Proteopedia
(Difference between revisions)
| Line 14: | Line 14: | ||
**[[3d0s]] – MtCAP – ''Mycobacterium tuberculosis'' <br /> | **[[3d0s]] – MtCAP – ''Mycobacterium tuberculosis'' <br /> | ||
**[[2wc2]] – EcCAP – ''Escherichia coli'' - NMR<br /> | **[[2wc2]] – EcCAP – ''Escherichia coli'' - NMR<br /> | ||
| - | **[[3hif]], [[4ft8]], [[4hzf]] – EcCAP <br /> | + | **[[3hif]], [[4ft8]], [[4hzf]], [[4n9h]] – EcCAP <br /> |
**[[3fwe]], [[4bh9]], [[4bhp]] – EcCAP (mutant) <br /> | **[[3fwe]], [[4bh9]], [[4bhp]] – EcCAP (mutant) <br /> | ||
| Line 22: | Line 22: | ||
**[[1hw5]], [[1i6x]], [[3kcc]], [[3qop]], [[3rdi]], [[3rou]], [[3rpq]] – EcCAP (mutant) + cAMP <br /> | **[[1hw5]], [[1i6x]], [[3kcc]], [[3qop]], [[3rdi]], [[3rou]], [[3rpq]] – EcCAP (mutant) + cAMP <br /> | ||
**[[3i54]], [[3i59]] – MtCAP + cAMP <br /> | **[[3i54]], [[3i59]] – MtCAP + cAMP <br /> | ||
| + | |||
| + | *CAP complex with cGMP | ||
| + | |||
| + | **[[4n9i]] – EcCAP + cGMP <br /> | ||
*CAP complex with cAMP and DNA | *CAP complex with cAMP and DNA | ||
Revision as of 11:08, 11 March 2015
Catabolite gene activator protein (CAP) is a DNA-binding protein involved in the transcription of several genes including those involved in the metabolism of sugar. CAP can activate or repress transcription initiation upon binding of cAMP. The cAMP-CAP complex binds to promoters on the DNA. The structure contains a ligand-binding domain (LBD) at the N-terminal and DNA-binding domain (DBD) at the C-terminal. Two cAMP molecules bind to the dimeric CAP. When the amount of glucose transported into the cell is low, cAMP level rises and the cAMP-CAP complex causes increase of transcription of glucose metabolism genes.
3D Structures of catabolite gene activator protein
Updated on 11-March-2015
