1lir
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1lir |SIZE=350|CAPTION= <scene name='initialview01'>1lir</scene> | |PDB= 1lir |SIZE=350|CAPTION= <scene name='initialview01'>1lir</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lir OCA], [http://www.ebi.ac.uk/pdbsum/1lir PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lir RCSB]</span> | ||
}} | }} | ||
| Line 34: | Line 37: | ||
[[Category: scorpion]] | [[Category: scorpion]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:03:18 2008'' |
Revision as of 19:03, 30 March 2008
| |||||||
| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
LQ2 FROM LEIURUS QUINQUESTRIATUS, NMR, 22 STRUCTURES
Overview
Lq2 is a unique scorpion toxin. Acting from the extracellular side, Lq2 blocks the ion conduction pore in not only the voltage- and Ca2+ -activated channels, but also the inward-rectifier K+ channels. This finding argues that the three-dimensional structures of the pores in these K+ channels are similar. However, the amino acid sequences that form the external part of the pore are minimally conserved among the various classes of K+ channels. Because Lq2 can bind to all the three classes of K+ channels, we can use Lq2 as a structural probe to examine how the non-conserved pore-forming sequences are arranged in space to form similar pore structures. In the present study, we determined the three-dimensional structure of Lq2 using nuclear magnetic resonance (NMR) techniques. Lq2 consists of an alpha-helix (residues S10 to L20) and a beta-sheet, connected by an alphabeta3 loop (residues N22 to N24). The beta-sheet has two well-defined anti-parallel strands (residues G26 to M29 and residues K32 to C35), which are connected by a type I' beta-turn centered between residues N30 and K31. The N-terminal segment (residues Z1 to T8) appears to form a quasi-third strand of the beta-sheet.
About this Structure
1LIR is a Single protein structure of sequence from Leiurus quinquestriatus hebraeus. Full crystallographic information is available from OCA.
Reference
Solution structure of potassium channel-inhibiting scorpion toxin Lq2., Renisio JG, Lu Z, Blanc E, Jin W, Lewis JH, Bornet O, Darbon H, Proteins. 1999 Mar 1;34(4):417-26. PMID:10081954
Page seeded by OCA on Sun Mar 30 22:03:18 2008
