1lk2
From Proteopedia
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|PDB= 1lk2 |SIZE=350|CAPTION= <scene name='initialview01'>1lk2</scene>, resolution 1.35Å | |PDB= 1lk2 |SIZE=350|CAPTION= <scene name='initialview01'>1lk2</scene>, resolution 1.35Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2vaa|2vaa]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lk2 OCA], [http://www.ebi.ac.uk/pdbsum/1lk2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lk2 RCSB]</span> | ||
}} | }} | ||
| Line 26: | Line 29: | ||
[[Category: Rudolph, M G.]] | [[Category: Rudolph, M G.]] | ||
[[Category: Wilson, I A.]] | [[Category: Wilson, I A.]] | ||
| - | [[Category: MPD]] | ||
| - | [[Category: MRD]] | ||
| - | [[Category: NAG]] | ||
| - | [[Category: PO4]] | ||
[[Category: anisotropic and tls refinement]] | [[Category: anisotropic and tls refinement]] | ||
[[Category: class i mhc-peptide complex]] | [[Category: class i mhc-peptide complex]] | ||
[[Category: high resolution]] | [[Category: high resolution]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:03:48 2008'' |
Revision as of 19:03, 30 March 2008
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| , resolution 1.35Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , | ||||||
| Related: | 2vaa
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide
Overview
We identify and consider some characteristics of a peptide antagonist for the Ag-specific receptor on 2C cells (the 2C TCR). The peptide, GNYSFYAL (called GNY), binds to H-2K(b), and a very high-resolution crystal structure of the GNY-K(b) complex at 1.35 A is described. Although the GNY peptide does not bind to L(d), the potency of GNY-K(b) as an antagonist is evident from its ability to specifically inhibit 2C TCR-mediated reactions to an allogenic agonist complex (QLSPFPFDL-L(d)), as well as to a syngeneic agonist complex (SIYRYYGL-K(b)). The crystal structure and the activities of alanine-substituted peptide variants point to the properties of the peptide P4 side chain and the conformation of the Tyr-P6 side chain as the structural determinants of GNYSFYAL antagonist activity.
About this Structure
1LK2 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects., Rudolph MG, Shen LQ, Lamontagne SA, Luz JG, Delaney JR, Ge Q, Cho BK, Palliser D, McKinley CA, Chen J, Wilson IA, Eisen HN, J Immunol. 2004 Mar 1;172(5):2994-3002. PMID:14978103
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