Molecular Playground/IntegrinBeta1
From Proteopedia
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==Function== | ==Function== | ||
| - | Integrins are a class of surface proteins that bind to | + | Integrins are a class of surface proteins that bind to extracellular matrix components and transmit chemical and mechanical cues to internal signaling pathways. Integrin beta 1 binds many proteins when dimerized with an alpha subunit, including collagen, laminin and fibronectin. |
==Disease== | ==Disease== | ||
Revision as of 18:41, 19 November 2014
One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground. Molecular Playground banner: "
Banner: Integrin Beta 1 binds to ECM proteins and allows for 3D in vitro cell migration
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Contents |
Structure
Here are the
Function
Integrins are a class of surface proteins that bind to extracellular matrix components and transmit chemical and mechanical cues to internal signaling pathways. Integrin beta 1 binds many proteins when dimerized with an alpha subunit, including collagen, laminin and fibronectin.
Disease
Studying Integrin Beta-1 in vitro
Peyton Lab Research Interests
The Peyton lab studies how cells process chemical and physical cues from the extracellular matrix and how these interactions play a role in the progression of cardiovascular disease and cancer. We aim to understand the downstream signaling pathways activated when cells use their integrins to bind to matrix and how this translates to the disease of interest.
References
Proteopedia Page Contributors and Editors (what is this?)
Lauren Barney, Lauren Jansen, Elizabeth Brooks, Michal Harel, Alyssa Schwartz
