This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Cocaine esterase
From Proteopedia
| Line 16: | Line 16: | ||
**[[3i2j]], [[3puh]] - RhCocE – ''Rhodococcus''<br /> | **[[3i2j]], [[3puh]] - RhCocE – ''Rhodococcus''<br /> | ||
| - | **[[1l7r]], [[3pui]] - RhCocE (mutant) | + | **[[1l7r]], [[3pui]], [[4p08]] - RhCocE (mutant) |
*Cocaine esterase binary complex | *Cocaine esterase binary complex | ||
Revision as of 10:12, 16 March 2015
Cocaine esterase (CocE) catalyzes the hydrolysis of the benzoyl ester of cocaine to ecgonine methyl ester and benzoic acid. CocE contains 3 domains. Domain 1 contains the catalytic triad: Ser, Asp and His typical of the hydrolase family. Domains 2 and 3 are involved in substrate recognition. CocE is produced by bacteria which thrive in soil of cocaine-producing plants. These bacteria use cocaine as their sole source of carbon and nitrogen. CocE is being investigated as a possible therapeutic agent for treatment of cocaine abuse.
3D structures of cocaine esterase
Updated on 16-March-2015
