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Cyclohydrolase
From Proteopedia
(Difference between revisions)
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• '''IMP cyclohydrolase''' catalyzes the conversion of IMP to formido-phosphosibosyl imidazole carboxamide. ICH is part of the purine biosynthesis<br /> | • '''IMP cyclohydrolase''' catalyzes the conversion of IMP to formido-phosphosibosyl imidazole carboxamide. ICH is part of the purine biosynthesis<br /> | ||
• '''Methenyltetrahydromethanopterin cyclohydrolase''' catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin. MCH is part of the folate biosynthesis<br /> | • '''Methenyltetrahydromethanopterin cyclohydrolase''' catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin. MCH is part of the folate biosynthesis<br /> | ||
| + | * '''Methylenetetrahydrofolate dehydrogenase/cyclohydrolase''' catalyzes the interconversion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate in mitochondria of mammalian cells. | ||
== Disease == | == Disease == | ||
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**[[1qlm]] – MCH – ''Methanopyrus kandleri''<br /> | **[[1qlm]] – MCH – ''Methanopyrus kandleri''<br /> | ||
| + | **[[4fio]] – MCH – ''Methanobrevibacter ruminatium''<br /> | ||
**[[4gvr]] – AfMCH – ''Archaeoglobus fulgidus''<br /> | **[[4gvr]] – AfMCH – ''Archaeoglobus fulgidus''<br /> | ||
**[[4gvq]] – AfMCH + tetrahydromethanopterin <br /> | **[[4gvq]] – AfMCH + tetrahydromethanopterin <br /> | ||
**[[4gvs]] – AfMCH + N5-formyl-tetrahydromethanopterin <br /> | **[[4gvs]] – AfMCH + N5-formyl-tetrahydromethanopterin <br /> | ||
| + | |||
| + | * Methylenetetrahydrofolate dehydrogenase/cyclohydrolase | ||
| + | |||
| + | **[[2c2x]], [[2c2y]] – MCH – ''Mycobacterium tuberculosis''<br /> | ||
| + | **[[1a4i]] – hMCH + NADP <br /> | ||
| + | **[[1dig]], [[1dia]], [[1dib]], [[1dig]] – hMCH + NADP + inhibitor<br /> | ||
*Phosphoribosyl-ATP cyclohydrolase | *Phosphoribosyl-ATP cyclohydrolase | ||
Revision as of 11:36, 18 March 2015
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3D structures of cyclohydrolase
Updated on 18-March-2015
