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Cyclophilin
From Proteopedia
(Difference between revisions)
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**[[1oca]] – hCyp-A - NMR<br /> | **[[1oca]] – hCyp-A - NMR<br /> | ||
**[[3k0o]], [[3k0p]], [[3k0q]], [[3k0r]], [[2alf]] – hCyp-A (mutant)<br /> | **[[3k0o]], [[3k0p]], [[3k0q]], [[3k0r]], [[2alf]] – hCyp-A (mutant)<br /> | ||
| + | **[[4dgd]] - RmCyp-A (mutant) – Rhesus macaque <br /> | ||
| + | **[[1ist]] – yCyp-A – yeast<br /> | ||
| + | **[[1w74]] – Cyp-A – ''Mycobacterium tuberculosis''<br /> | ||
| + | **[[3o7t]] – NpCyp-A – ''Noniliophthora perniciosa''<br /> | ||
| + | **[[4e1q]] – Cyp-A – wheat<br /> | ||
| + | **[[4eyv]] – Cyp-A – ''Piriformospora indica''<br /> | ||
| + | |||
| + | * Cyclophilin-A complex | ||
| + | |||
**[[2a2c]], [[1cwa]], [[1cwb]], [[1cwc]], [[2x2c]] – hCyp-A+cyclosporin A<br /> | **[[2a2c]], [[1cwa]], [[1cwb]], [[1cwc]], [[2x2c]] – hCyp-A+cyclosporin A<br /> | ||
**[[3cys]] - hCyp-A+cyclosporin A - NMR<br /> | **[[3cys]] - hCyp-A+cyclosporin A - NMR<br /> | ||
| Line 20: | Line 29: | ||
**[[3odi]], [[3odl]] – hCyp-A+voclosporin<br /> | **[[3odi]], [[3odl]] – hCyp-A+voclosporin<br /> | ||
**[[2x2d]], [[1m9c]], [[1m9d]], [[1m9e]], [[1m9f]], [[1m9x]], [[1m9y]], [[1awq]], [[1awr]], [[1aws]], [[1awt]], [[1awu]], [[1awv]], [[1ak4]], [[1fgl]] - hCyp-A+HIV-1 N-terminal capsid domain<br /> | **[[2x2d]], [[1m9c]], [[1m9d]], [[1m9e]], [[1m9f]], [[1m9x]], [[1m9y]], [[1awq]], [[1awr]], [[1aws]], [[1awt]], [[1awu]], [[1awv]], [[1ak4]], [[1fgl]] - hCyp-A+HIV-1 N-terminal capsid domain<br /> | ||
| - | **[[4dga]], [[4dgb]], [[4dgc]] - RmCyp-A+HIV-1 Cyp-binding domain capsid protein (mutant) | + | **[[4dga]], [[4dgb]], [[4dgc]] - RmCyp-A+HIV-1 Cyp-binding domain capsid protein (mutant) <br /> |
**[[4dge]] - RmCyp-A (mutant) +HIV-1 Cyp-binding domain capsid protein (mutant) <br /> | **[[4dge]] - RmCyp-A (mutant) +HIV-1 Cyp-binding domain capsid protein (mutant) <br /> | ||
| - | **[[4dgd]] - RmCyp-A (mutant)<br /> | ||
**[[1zkf]] – hCyp-A+suc-AGPF-pNA<br /> | **[[1zkf]] – hCyp-A+suc-AGPF-pNA<br /> | ||
**[[1ynd]], [[1nmk]] – hCyp-A+ sanglifehrin<br /> | **[[1ynd]], [[1nmk]] – hCyp-A+ sanglifehrin<br /> | ||
| Line 28: | Line 36: | ||
**[[1vbs]], [[1vbt]] – hCyp-A+tetrapeptide<br /> | **[[1vbs]], [[1vbt]] – hCyp-A+tetrapeptide<br /> | ||
**[[1vdn]] – yCyp-A+peptidyl coumarin – yeast<br /> | **[[1vdn]] – yCyp-A+peptidyl coumarin – yeast<br /> | ||
| - | **[[1ist]] – yCyp-A<br /> | ||
| - | **[[1w74]] – Cyp-A – ''Mycobacterium tuberculosis''<br /> | ||
**[[1lop]] - EcCyp-A+peptidyl nitroanilide - ''Escherichia coli''<br /> | **[[1lop]] - EcCyp-A+peptidyl nitroanilide - ''Escherichia coli''<br /> | ||
**[[1csa]] – EcCyp-A+ cyclosporin A – NMR<br /> | **[[1csa]] – EcCyp-A+ cyclosporin A – NMR<br /> | ||
| Line 36: | Line 42: | ||
**[[3pmp]] - NpCyp-A + cyclosporin A<br /> | **[[3pmp]] - NpCyp-A + cyclosporin A<br /> | ||
**[[3rdd]] – hCyp-A + inhibitor<br /> | **[[3rdd]] – hCyp-A + inhibitor<br /> | ||
| + | **[[3t1u]] – Cyp-A + peptide – ''Azotobacter vinelandii''<br /> | ||
* Cyclophilin-B | * Cyclophilin-B | ||
| Line 44: | Line 51: | ||
**[[1vai]] - EcCyp-B+peptidyl coumarin<br /> | **[[1vai]] - EcCyp-B+peptidyl coumarin<br /> | ||
**[[1cyn]] – hCyp-B +cyclosporin A derivative<br /> | **[[1cyn]] – hCyp-B +cyclosporin A derivative<br /> | ||
| + | **[[2rs4]] – EcCyp-B - NMR<BR /> | ||
**[[1j2a]] – EcCyp-B (mutant)<br /> | **[[1j2a]] – EcCyp-B (mutant)<br /> | ||
| + | **[[4fru]] – hoCyp-B – horse<br /> | ||
| + | **[[4frv]] – hoCyp-B (mutant)<br /> | ||
| + | **[[1a58]], [[4jcp]] – Cyp-B – ''Brugia malayi''<br /> | ||
* Cyclophilin-C | * Cyclophilin-C | ||
| Line 50: | Line 61: | ||
**[[2esl]] - hCyp-C+cyclosporin A<br /> | **[[2esl]] - hCyp-C+cyclosporin A<br /> | ||
**[[2rmc]] - Cyp-C+cyclosporin A – mouse<br /> | **[[2rmc]] - Cyp-C+cyclosporin A – mouse<br /> | ||
| + | **[[1jns]], [[1jnt]] – EcCyp-C - NMR<BR /> | ||
* Cyclophilin-D | * Cyclophilin-D | ||
| Line 90: | Line 102: | ||
**[[1h0p]] – CeCyp-5 (mutant) <br /> | **[[1h0p]] – CeCyp-5 (mutant) <br /> | ||
| + | |||
| + | * Cyclophilin-38 | ||
| + | |||
| + | **[[3rfy]] – Cyp-38 – ''Arabidopsis thaliana''<br /> | ||
* Cyclophilin-40 | * Cyclophilin-40 | ||
| Line 114: | Line 130: | ||
**[[1xo7]] – TcCyp – ''Trypanosoma cruzi''<br /> | **[[1xo7]] – TcCyp – ''Trypanosoma cruzi''<br /> | ||
**[[1xq7]] - TcCyp+cyclosporin A<br /> | **[[1xq7]] - TcCyp+cyclosporin A<br /> | ||
| - | **[[ | + | **[[2ko7]], [[2l2s]] – BpCyp+inhibitor – ''Burkholderia pseudomallei''<br /> |
| - | + | **[[2ke0]], [[3s6m]] – BpCyp – NMR<br /> | |
| - | **[[2ke0]] – BpCyp – NMR | + | **[[4dz2]], [[4dz3]] – BpPin1 (mutant) + FK506<BR /> |
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:58, 10 May 2015
Cyclophilin (Cyp) binds cyclosporin. They are peptidylprolyl isomerases which catalyze the isomerisation of proline. The Cyp-A/cyclosporin A complex inhibits organ rejection. Cyp-D is a component of the mitochondria permeability pore. Rotamase such as FKBP is a prokaryotic Cyp which is not inhibited by cyclosporin but by FK-506 – an immunosuppressive drug.
3D Structures of Cyclophilin
Updated on 10-May-2015
