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Cytochrome P450
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_2f9q| PDB=2f9q | SIZE=400| SCENE=Cytochrome_P450/Cv/1 |right|CAPTION=Cytochrome P450 tetramer with heme and sulfate ions [[2f9q]] }} | {{STRUCTURE_2f9q| PDB=2f9q | SIZE=400| SCENE=Cytochrome_P450/Cv/1 |right|CAPTION=Cytochrome P450 tetramer with heme and sulfate ions [[2f9q]] }} | ||
| - | [[Cytochrome P450]] (P450) catalyzes the oxidation of organic substances like lipids. catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene. P450cam, also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor. P450nor is a Nitric Oxide Reductase P450. P450epoK converts epothilone D to epothilone B. P450cin monooxygenates 1,8-cineole which is similar to camphor. | + | [[Cytochrome P450]] (P450) catalyzes the oxidation of organic substances like lipids. catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene. For details on the human P45019 family see [[Aromatase]].<br /> |
| + | * '''P450cam''', also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor.<br /> | ||
| + | * '''P450nor''' is a Nitric Oxide Reductase P450.<br /> | ||
| + | * '''P450epoK''' converts epothilone D to epothilone B.<br /> | ||
| + | * '''P450cin''' monooxygenates 1,8-cineole which is similar to camphor.<br /> | ||
| + | * '''Bifunctional P450/NADPH P450 reductase''' (P450 BM3) is a fatty acid monooxygenase.<br /> | ||
| + | Additional details in [[Drug Metabolism by CYP450 Enzymes]]. | ||
== 3D Structures of Cytochrome P450 == | == 3D Structures of Cytochrome P450 == | ||
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**[[2z10]] – hP4502A6+coumarin<br /> | **[[2z10]] – hP4502A6+coumarin<br /> | ||
**[[1z11]] - hP4502A6+methoxalen<br /> | **[[1z11]] - hP4502A6+methoxalen<br /> | ||
| + | **[[4rui]] – hP450 2A6 + volatile hydrocarbon<br /> | ||
**[[3t3s]] - hP4502A13 + pilocarpine<br /> | **[[3t3s]] - hP4502A13 + pilocarpine<br /> | ||
**[[4ejg]] - hP4502A13 + nicotine<br /> | **[[4ejg]] - hP4502A13 + nicotine<br /> | ||
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**[[3ua5]] – hP4502B6 (mutant) + amlodipine<br /> | **[[3ua5]] – hP4502B6 (mutant) + amlodipine<br /> | ||
**[[4i91]] - hP4502B6 (mutant) + pinine<br /> | **[[4i91]] - hP4502B6 (mutant) + pinine<br /> | ||
| + | **[[3qoa]], [[2qu8]], [[3qu8]] – hP450 2B6 (mutant) + inhibitor<br /> | ||
| + | **[[4rql]], [[4rrt]] – hP450 2B6 (mutant) + volatile hydrocarbon<br /> | ||
**[[2nnh]] – hP4502C8+retinoic acid<br /> | **[[2nnh]] – hP4502C8+retinoic acid<br /> | ||
**[[2nni]] - hP4502C8+montelukast<br /> | **[[2nni]] - hP4502C8+montelukast<br /> | ||
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**[[1og2]], [[1og5]] – hP4502C9 (mutant)<br /> | **[[1og2]], [[1og5]] – hP4502C9 (mutant)<br /> | ||
**[[1r9o]] – hP4502C9 (mutant)+flurbiprofen<br /> | **[[1r9o]] – hP4502C9 (mutant)+flurbiprofen<br /> | ||
| + | **[[4nz2]] - hP4502C9 (mutant) + inhibitor<br /> | ||
**[[4gqs]] - hP4502C19 catalytic domain<br /> | **[[4gqs]] - hP4502C19 catalytic domain<br /> | ||
**[[2f9q]], [[3qm4]] – hP4502D6<br /> | **[[2f9q]], [[3qm4]] – hP4502D6<br /> | ||
| - | **[[3tbg]] – hP4502D6 + thioridazine<br /> | + | **[[3tbg]], [[4wnw]] – hP4502D6 + thioridazine<br /> |
**[[3tda]] – hP4502D6 + prinomastat<br /> | **[[3tda]] – hP4502D6 + prinomastat<br /> | ||
| + | **[[4wnt]] - hP4502D6 + ajmalicine<br /> | ||
| + | **[[4wnu]], [[4wnv]] - hP4502D6 + quinine derivative<br /> | ||
**[[3gph]], [[3koh]], [[3lc4]] – hP4502E1 fragment +imidazole derivative<br /> | **[[3gph]], [[3koh]], [[3lc4]] – hP4502E1 fragment +imidazole derivative<br /> | ||
**[[3e6i]] – hP4502E1 fragment+indazole<br /> | **[[3e6i]] – hP4502E1 fragment+indazole<br /> | ||
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**[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br /> | **[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br /> | ||
**[[4i3q]] - hP4503A4 (mutant) <br /> | **[[4i3q]] - hP4503A4 (mutant) <br /> | ||
| + | **[[4ny4]] - hP4503A4 + inhibitor <br /> | ||
* human P450 7 family | * human P450 7 family | ||
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**[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]],[[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]] – PpP450cam(mutant) – ''Pseudomona putida''<br /> | **[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]],[[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]] – PpP450cam(mutant) – ''Pseudomona putida''<br /> | ||
| - | **[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]] - PpP450cam<br /> | + | **[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]], [[3wrh]], [[3wri]], [[3wrk]] - PpP450cam<br /> |
**[[2qbo]] - PpP450cam (mutant)+cyanide<br /> | **[[2qbo]] - PpP450cam (mutant)+cyanide<br /> | ||
**[[1qmq]] - PpP450cam (mutant)+Ru substrate<br /> | **[[1qmq]] - PpP450cam (mutant)+Ru substrate<br /> | ||
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**[[4l49]], [[4l4a]], [[4l4b]], [[4l4c]] - PpP450cam (mutant)+ camphor<br /> | **[[4l49]], [[4l4a]], [[4l4b]], [[4l4c]] - PpP450cam (mutant)+ camphor<br /> | ||
**[[4l4d]], [[4l4e]], [[4l4f]], [[4l4g]] - PpP450cam (mutant)+ camphor + CN<br /> | **[[4l4d]], [[4l4e]], [[4l4f]], [[4l4g]] - PpP450cam (mutant)+ camphor + CN<br /> | ||
| + | **[[4kky]] - PpP450cam (mutant)+ camphor + pyrene derivative<br /> | ||
**[[2l8m]] – PpP450cam+camphor+CO<br /> | **[[2l8m]] – PpP450cam+camphor+CO<br /> | ||
**[[4g3r]] – PpP450cam+camphor+NO<br /> | **[[4g3r]] – PpP450cam+camphor+NO<br /> | ||
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**[[1po5]], [[3mvr]], [[3r1a]], [[3r1b]] - rP4502B4 (mutant)<br /> | **[[1po5]], [[3mvr]], [[3r1a]], [[3r1b]] - rP4502B4 (mutant)<br /> | ||
**[[1suo]],[[3g5n]], [[3g93]], [[2q6n]] - rP4502B4 (mutant)+imidazole derivative<br /> | **[[1suo]],[[3g5n]], [[3g93]], [[2q6n]] - rP4502B4 (mutant)+imidazole derivative<br /> | ||
| + | **[[4mgj]] - rP4502B4 (mutant)+ thiol derivative<br /> | ||
**[[3kw4]], [[3me6]], [[3tmz]], [[4h1n]] - rP4502B4 (mutant)+anti-platelet drug<br /> | **[[3kw4]], [[3me6]], [[3tmz]], [[4h1n]] - rP4502B4 (mutant)+anti-platelet drug<br /> | ||
**[[3uas]] - rP4502B4 (mutant)+ inactivator<br /> | **[[3uas]] - rP4502B4 (mutant)+ inactivator<br /> | ||
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**[[3cbd]] – BmP450 heme domain – ''Bacillus megaterium''<br /> | **[[3cbd]] – BmP450 heme domain – ''Bacillus megaterium''<br /> | ||
| - | **[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]] - BmP450 heme domain (mutant)<br /> | + | **[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]] - BmP450 heme domain (mutant)<br /> |
**[[4dtw]], [[4due]], [[4duf]] - BmP450 heme domain (mutant) + serotonin<br /> | **[[4dtw]], [[4due]], [[4duf]] - BmP450 heme domain (mutant) + serotonin<br /> | ||
**[[4dtz]], [[4du2]], [[4dub]] - BmP450 heme domain (mutant) + dopamine<br /> | **[[4dtz]], [[4du2]], [[4dub]] - BmP450 heme domain (mutant) + dopamine<br /> | ||
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**[[2x7y]], [[2x80]] - BmP450 heme domain (mutant) + DMSO<br /> | **[[2x7y]], [[2x80]] - BmP450 heme domain (mutant) + DMSO<br /> | ||
**[[4hgf]], [[4hgg]], [[4hgh]], [[4hgi]] - BmP450 heme domain (mutant) + styrene<br /> | **[[4hgf]], [[4hgg]], [[4hgh]], [[4hgi]] - BmP450 heme domain (mutant) + styrene<br /> | ||
| - | **[[4kew]], [[4key]] - BmP450 heme domain (mutant) + omeprazole<br /> | + | **[[4kew]], [[4key]], [[4o4p]] - BmP450 heme domain (mutant) + omeprazole<br /> |
**[[3ekb]], [[3ekd]], [[3ekf]], [[2ij3]], [[2ij4]] - BmP450102 heme domain (mutant)<br /> | **[[3ekb]], [[3ekd]], [[3ekf]], [[2ij3]], [[2ij4]] - BmP450102 heme domain (mutant)<br /> | ||
**[[2ij2]], [[2hpd]] - BmP450102 heme domain<br /> | **[[2ij2]], [[2hpd]] - BmP450102 heme domain<br /> | ||
**[[4dqk]] - BmP450 FAD domain + FAD<br /> | **[[4dqk]] - BmP450 FAD domain + FAD<br /> | ||
**[[4dql]] - BmP450 FAD domain + NADP + FAD<br /> | **[[4dql]] - BmP450 FAD domain + NADP + FAD<br /> | ||
| + | **[[3wsp]] - BmP450 + decoy molecule<br /> | ||
**[[2uwh]] - BmP450102+palmitic acid<br /> | **[[2uwh]] - BmP450102+palmitic acid<br /> | ||
**[[3ben]] - BmP450102 + imidazole derivative<br /> | **[[3ben]] - BmP450102 + imidazole derivative<br /> | ||
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**[[1io9]], [[1io7]], [[1f4u]] - SsP450119<br /> | **[[1io9]], [[1io7]], [[1f4u]] - SsP450119<br /> | ||
**[[1f4t]] - SsP450119+ phenylimidazole<br /> | **[[1f4t]] - SsP450119+ phenylimidazole<br /> | ||
| + | **[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br /> | ||
**[[1cpt]] – P450108 – ''Pseudomonas sp.''<br /> | **[[1cpt]] – P450108 – ''Pseudomonas sp.''<br /> | ||
| - | **[[4l0e]], [[4l0f]] - | + | **[[4l0e]], [[4l0f]] - StP450 SKY32– ''Streptomyces''<br /> |
| + | **[[4pwv]], [[4pxh]] - StP450 SKY32 + peptidyl carrier protein domain<br /> | ||
| + | **[[4r20]], [[4r21]] - P45017A2 – zebra fish<br /> | ||
**[[3aba]] – SaP450105P1+filipin I – ''Streptomyces avermitilis''<br /> | **[[3aba]] – SaP450105P1+filipin I – ''Streptomyces avermitilis''<br /> | ||
**[[3abb]] – SaP450105D6<br /> | **[[3abb]] – SaP450105D6<br /> | ||
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**[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br /> | **[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br /> | ||
**[[2zqx]] - BsP450152A1+heptanoic acid<br /> | **[[2zqx]] - BsP450152A1+heptanoic acid<br /> | ||
| + | **[[4rm4]] - BsP450109B1<br /> | ||
**[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450134A1 (mutant)<br /> | **[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450134A1 (mutant)<br /> | ||
**[[1izo]] – BsP450 BS beta+ palmitoleic acid<br /> | **[[1izo]] – BsP450 BS beta+ palmitoleic acid<br /> | ||
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**[[3awm]] – SpP450-α + palmitic acid – ''Sphingomonas paucimobilis''<br /> | **[[3awm]] – SpP450-α + palmitic acid – ''Sphingomonas paucimobilis''<br /> | ||
**[[3awp]], [[3awq]] - SpP450-α (mutant)<br /> | **[[3awp]], [[3awq]] - SpP450-α (mutant)<br /> | ||
| - | **[[3qoa]], [[2qu8]], [[3qu8]] – hP450 2b6 (mutant) + inhibitor<br /> | ||
**[[3a4g]], [[3a4h]] – PaP450 VDH – ''Pseudonocardia autotrophica''<br /> | **[[3a4g]], [[3a4h]] – PaP450 VDH – ''Pseudonocardia autotrophica''<br /> | ||
**[[3a4z]] - PaP450 VDH (mutant)<br /> | **[[3a4z]] - PaP450 VDH (mutant)<br /> | ||
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**[[3o1a]] – P450 165D3 – ''Actinoplanes teichomyceticus''<br /> | **[[3o1a]] – P450 165D3 – ''Actinoplanes teichomyceticus''<br /> | ||
**[[3wec]] – P450 + dihydroxy-aurachin Re – ''Rhodococcus erythropolis''<br /> | **[[3wec]] – P450 + dihydroxy-aurachin Re – ''Rhodococcus erythropolis''<br /> | ||
| + | **[[4e2p]] - P450 – ''Streptococcus himastatinicus''<br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:25, 19 March 2015
Cytochrome P450 (P450) catalyzes the oxidation of organic substances like lipids. catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene. For details on the human P45019 family see Aromatase.
- P450cam, also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor.
- P450nor is a Nitric Oxide Reductase P450.
- P450epoK converts epothilone D to epothilone B.
- P450cin monooxygenates 1,8-cineole which is similar to camphor.
- Bifunctional P450/NADPH P450 reductase (P450 BM3) is a fatty acid monooxygenase.
Additional details in Drug Metabolism by CYP450 Enzymes.
3D Structures of Cytochrome P450
Updated on 19-March-2015
