Deoxyuridine 5'-triphosphate nucleotidohydrolase
From Proteopedia
(Difference between revisions)
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**[[1dun]] – EvDUTP – Equine infectious anemia virus<br /> | **[[1dun]] – EvDUTP – Equine infectious anemia virus<br /> | ||
**[[1mq7]] – MtDUTP – ''Mycobacterium tuberculosis''<br /> | **[[1mq7]] – MtDUTP – ''Mycobacterium tuberculosis''<br /> | ||
| + | **[[4gk6]] - DUTP – ''Mycobacterium abscessus''<br /> | ||
**[[1ogl]] – TcDUTP – ''Trypanosoma cruzi''<br /> | **[[1ogl]] – TcDUTP – ''Trypanosoma cruzi''<br /> | ||
**[[2d4l]] - MPmvDUTP residues 83-234 – Mason_Pfizer monkey virus<br /> | **[[2d4l]] - MPmvDUTP residues 83-234 – Mason_Pfizer monkey virus<br /> | ||
| Line 40: | Line 41: | ||
**[[1smc]] - MtDUTP + dUTP<br /> | **[[1smc]] - MtDUTP + dUTP<br /> | ||
**[[4gcy]] - MtDUTP (mutant) + dUTP<br /> | **[[4gcy]] - MtDUTP (mutant) + dUTP<br /> | ||
| - | **[[1vyq]], [[3t60]], [[3t64]] - PfDUTP + uridine derivative inhibitor – ''Plasmodium falciparum''<br /> | + | **[[1vyq]], [[3t60]], [[3t64]], [[3t6y]], [[3t70]] - PfDUTP + uridine derivative inhibitor – ''Plasmodium falciparum''<br /> |
**[[2y8c]] - PfDUTP + trityl ligand<br /> | **[[2y8c]] - PfDUTP + trityl ligand<br /> | ||
**[[2bsy]], [[2we0]] - EbvDUTP + dUMP – Epstein-Barr virus<br /> | **[[2bsy]], [[2we0]] - EbvDUTP + dUMP – Epstein-Barr virus<br /> | ||
Revision as of 08:27, 23 March 2015
Deoxyuridine 5’-triphosphate nucleotidohydrolase (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. DUTP inhibitors are being tested as possible anti-bacterial agents targeting diseases like malaria, leishmaniasis, tuberculosis and trypanosomiasis. Prokaryotic DUTP contains metal ion.
3D structures of dUTPase
Updated on 23-March-2015
