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Diphtheria toxin
From Proteopedia
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== Function == | == Function == | ||
| - | '''Diphtheria toxin''' (DT) is a toxin which is secreted by the bacteria causing diphtheria | + | '''Diphtheria toxin''' (DT) is a toxin which is secreted by the bacteria causing diphtheria. DT catalyzes the transfer of NAD to a diphthamide residue in the elongatin factor-2 and thus inhibiting protein synthesis. |
== Disease == | == Disease == | ||
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== Relevance == | == Relevance == | ||
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| + | DT is used in several drugs as chemotherapeutic agent and as an immunotoxin. | ||
== Structural highlights == | == Structural highlights == | ||
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| + | DT is proteolitically cleaved into 2 fragments. Fragment A contains the catalytic domain (C) and fragment B contains the transmembrane (T) and receptor-binding (R) domains. DT active site is located in a cleft in the C domain.<ref>PMID:7833807</ref> | ||
</StructureSection> | </StructureSection> | ||
Revision as of 12:15, 30 December 2015
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3D structures of diphtheria toxin
Updated on 30-December-2015
References
- ↑ Bennett MJ, Choe S, Eisenberg D. Refined structure of dimeric diphtheria toxin at 2.0 A resolution. Protein Sci. 1994 Sep;3(9):1444-63. PMID:7833807
