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Estrogen receptor

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**[[2bj4]], [[2jf9]], [[2jfa]], [[1pcg]] - hERα LBD + peptide antagonist<br />
**[[2bj4]], [[2jf9]], [[2jfa]], [[1pcg]] - hERα LBD + peptide antagonist<br />
**[[2yja]] - hERα LBD + stapled peptide<br />
**[[2yja]] - hERα LBD + stapled peptide<br />
 +
**[[2q6j]], [[2p15]], [[3erd]], [[1l2i]] - hERα LBD + GRIP peptide<br />
**[[2yat]] - hERα LBD (mutant) + EST derivative<br />
**[[2yat]] - hERα LBD (mutant) + EST derivative<br />
**[[3uuc]] - hERα LBD + bisphenol<br />
**[[3uuc]] - hERα LBD + bisphenol<br />
 +
**[[3q97]] - hERα LBD + LXXLL motif (mutant) + ethoxy triphenylethylene<br />
 +
**[[1gwr]] - hERα LBD + TIF2 peptide + EST<br />
 +
**[[2ocf]] - hERα LBD (mutant) + fibronectin domain 10 + EST<br />
-
*''ERα LBD ternary complex with steroid receptor coactivator peptide''
+
*''ERα LBD ternary complex with steroid receptor coactivator 1 peptide''
-
**[[2b23]], [[3uu7]], [[3uua]], [[3uud]] - hERα LBD (mutant) + nuclear receptor coactivator peptide<br />
+
**[[3uu7]], [[3uua]], [[3uud]] - hERα LBD (mutant) + nuclear receptor coactivator 1 peptide<br />
-
**[[3erd]], [[1l2i]] - hERα LBD + nuclear receptor coactivator peptide + nonsteroidal EST<BR />
+
**[[4dma]] - hERα LBD (mutant) + nuclear receptor coactivator 1 peptide + inhibitor<br />
-
**[[1gwr]] - hERα LBD + nuclear receptor coactivator peptide + EST<BR />
+
**[[4mg5]], [[4mg6]], [[4mg7]], [[4mg8]], [[4mg9]], [[4mga]], [[4mgb]], [[4mgc]], [[4mgd]] - hERα LBD (mutant) + nuclear receptor coactivator 1 peptide + ligand<br />
-
**[[3q95]] - hERα LBD (mutant) + nuclear receptor coactivator peptide + EST<BR />
+
**[[4tuz]] - hERα LBD (mutant) + steroid receptor coactivator 1 peptide + toxin<br />
-
**[[4dma]], [[4iu7]], [[4iui]], [[4iv2]], [[4iv4]], [[4ivw]], [[4ivy]], [[4iw6]], [[4iw8]], [[4iwc]], [[4iwf]] - hERα LBD (mutant) + nuclear receptor coactivator peptide + inhibitor<br />
+
**[[4tv1]] - hERα LBD (mutant) + steroid receptor coactivator 1 peptide + preservative<br />
-
**[[2g5o]] - hERα LBD + nuclear receptor coactivator peptide + EST derivative<br />
+
 
-
**[[2p15]], [[2qgt]] - hERα LBD (mutant) + nuclear receptor coactivator peptide + EST derivative<br />
+
*''ERα LBD ternary complex with steroid receptor coactivator 2 peptide''
-
**[[1gwq]], [[1x7e]], [[2fai]], [[2g44]], [[2q6j]], [[2qzo]] - hERα LBD + nuclear receptor coactivator peptide + ligand<br />
+
 
-
**[[1zky]], [[2b1v]], [[2b1z]], [[2qa6]], [[2qab]], [[2qgw]], [[2qh6]], [[2qr9]], [[2qse]], [[2qxm]], [[3hlv]], [[3hm1]], [[3l03]], [[3q97]], [[3dma]] - hERα LBD (mutant) + nuclear receptor coactivator peptide + ligand<br />
+
**[[2b23]] - hERα LBD (mutant) + nuclear receptor coactivator 2 peptide<br />
-
**[[1x7r]] - hERα LBD + steroid receptor coactivator peptide + genistein<br />
+
**[[3q95]] - hERα LBD (mutant) + nuclear receptor coactivator 2 peptide + EST<br />
-
**[[2qa8]] - hERα LBD (mutant) + steroid receptor coactivator peptide + genistein<br />
+
**[[4iu7]], [[4iui]], [[4iv2]], [[4iv4]], [[4ivw]], [[4ivy]], [[4iw6]], [[4iw8]], [[4iwc]], [[4iwf]] - hERα LBD (mutant) + nuclear receptor coactivator 2 peptide + inhibitor<br />
-
**[[2ocf]] - hERα LBD (mutant) + fibronectin domain 10 + EST<BR />
+
**[[2g5o]] - hERα LBD + nuclear receptor coactivator 2 peptide + EST derivative<br />
 +
**[[2qgt]] - hERα LBD (mutant) + nuclear receptor coactivator 2 peptide + EST derivative<br />
 +
**[[1gwq]], [[2fai]], [[2g44]], [[2qzo]] - hERα LBD + nuclear receptor coactivator 2 peptide + ligand<br />
 +
**[[3l03]], [[3hm1]], [[3hlv]], [[1zky]], [[2b1v]], [[2b1z]], [[2qa6]], [[2qab]], [[2qgw]], [[2qh6]], [[2qr9]], [[2qse]], [[2qxm]] - hERα LBD (mutant) + nuclear receptor coactivator 2 peptide + ligand<br />
 +
**[[2qa8]] - hERα LBD (mutant) + steroid receptor coactivator 2 peptide + genistein<br />
 +
**[[4pp6]], [[4ppp]], [[4pps]] - hERα LBD (mutant) + steroid receptor coactivator peptide 2 + resveratrol derivative<br />
 +
 
 +
*''ERα LBD ternary complex with steroid receptor coactivator 3 peptide''
 +
 
 +
**[[1x7r]] - hERα LBD + steroid receptor coactivator 3 peptide + genistein<br />
 +
**[[1x7e]] - hERα LBD + nuclear receptor coactivator 3 peptide + ligand<br />
*Estrogen receptor β ligand binding domain
*Estrogen receptor β ligand binding domain
Line 54: Line 68:
**[[2yly]] - hERβ LBD + sulfonamide agonist<br />
**[[2yly]] - hERβ LBD + sulfonamide agonist<br />
**[[2fsz]] - hERβ LBD (mutant) + ligand<br />
**[[2fsz]] - hERβ LBD (mutant) + ligand<br />
-
**[[2yja]] - hERβ LBD + stapled peptide<br />
+
**[[2yja]], [[2yjd]] - hERβ LBD + stapled peptide<br />
**[[4j24]], [[4j26]] - hERβ LBD + peptide<br />
**[[4j24]], [[4j26]] - hERβ LBD + peptide<br />

Revision as of 10:07, 31 March 2015

Human estrogen receptor-ligand binding domain (grey and green) complex with transcription intermediate factor-2 peptide (pink and yellow) and estradiol (PDB code 1gwr)

Drag the structure with the mouse to rotate


3D structures of estrogen receptor

Updated on 31-March-2015


Reference

  1. ↑ Li MJ, Greenblatt HM, Dym O, Albeck S, Pais A, Gunanathan C, Milstein D, Degani H, Sussman JL. Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators. J Med Chem. 2011 Apr 7. PMID:21473635 doi:10.1021/jm200192y

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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