Ferritin

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Line 26: Line 26:
**[[1krq]] – FR – ''Campylobacter jejuni''<br />
**[[1krq]] – FR – ''Campylobacter jejuni''<br />
**[[1eum]] - EcFR – ''Escherichia coli''<br />
**[[1eum]] - EcFR – ''Escherichia coli''<br />
 +
**[[4reu]] – EcFR + Fe<br />
**[[1qgh]] – LiFR - ''Listeria innocua''<br />
**[[1qgh]] – LiFR - ''Listeria innocua''<br />
**[[1mfr]], [[1bg7]], [[3ka3]], [[3ka4]], [[3rbc]], [[3re7]], [[3rgd]], [[4das]] – bFR - Bullfrog<br />
**[[1mfr]], [[1bg7]], [[3ka3]], [[3ka4]], [[3rbc]], [[3re7]], [[3rgd]], [[4das]] – bFR - Bullfrog<br />
Line 33: Line 34:
**[[3vnx]] – FR – ''Ulva pertusa''<br />
**[[3vnx]] – FR – ''Ulva pertusa''<br />
**[[4ism]], [[4isp]], [[4itt]], [[4itw]], [[4iwj]], [[4iwk]], [[4ixk]] – FR – ''Pseudo-nitschia multiseries''<br />
**[[4ism]], [[4isp]], [[4itt]], [[4itw]], [[4iwj]], [[4iwk]], [[4ixk]] – FR – ''Pseudo-nitschia multiseries''<br />
-
**[[1z6o]] – FTH – ''Trichoplusia ni''<br />
+
**[[1z6o]] – FR – ''Trichoplusia ni''<br />
 +
**[[4cmy]] – FR + Fe – ''Chlorobaculum tepidum''<br />
*Ferritin light chain (FTL)
*Ferritin light chain (FTL)
-
**[[1lb3]], [[1h96]] – FTL – mouse<br />
+
**[[1lb3]], [[1h96]] – mFTL – mouse<br />
**[[1rcc]], [[1rcd]], [[1rci]] – bFTL+tartrate+Mg<br />
**[[1rcc]], [[1rcd]], [[1rci]] – bFTL+tartrate+Mg<br />
**[[1rce]], [[1rcg]] - bFTL+tartrate+Mn<br />
**[[1rce]], [[1rcg]] - bFTL+tartrate+Mn<br />
**[[3noz]], [[3np0]], [[3np2]], [[3o7r]] – hoFTL (mutant) - horse<br />
**[[3noz]], [[3np0]], [[3np2]], [[3o7r]] – hoFTL (mutant) - horse<br />
**[[3o7s]], [[3u90]] - hoFTL<br />
**[[3o7s]], [[3u90]] - hoFTL<br />
 +
**[[4v1w]] – hoFTL – cryo EM<br />
**[[3rav]], [[3rd0]] – hoFTL + barbiturate
**[[3rav]], [[3rd0]] – hoFTL + barbiturate
Line 48: Line 51:
**[[2z6m]], [[1r03]], [[2fha]], [[3ajo]] – hFTH<br />
**[[2z6m]], [[1r03]], [[2fha]], [[3ajo]] – hFTH<br />
**[[3ajp]], [[3ajq]], [[4dyx]], [[4dyy]], [[4dyz]], [[4dz0]] - hFTH (mutant)<br />
**[[3ajp]], [[3ajq]], [[4dyx]], [[4dyy]], [[4dyz]], [[4dz0]] - hFTH (mutant)<br />
 +
**[[3wnw]] – mFTH<br />
 +
 +
*Ferritin middle subunit (FTM)
 +
 +
**[[4lpj]], [[4lqj]], [[4lqn]], [[4lqv]], [[4lyu]], [[4lyx]], [[4my7]] – bFTM + Fe – bullfrog<br />
 +
**[[4lpm]], [[4mku]] – bFTM (mutant) + Mg<br />
 +
**[[4lpn]] – bFTM (mutant) + Co<br />
 +
**[[4mjy]], [[4ml5]], [[4mn9]] – bFTM (mutant) + Fe<br />
 +
**[[4p18]] – bFTM (mutant) <br />
 +
**[[4lqh]] – bFTM + Mg<br />
*apo-ferritin (apo-FR)
*apo-ferritin (apo-FR)
Line 92: Line 105:
**[[3is7]], [[3is8]], [[3ise]], [[3isf]], [[3r2h]], [[3r2k]], [[3r2l]], [[3r2m]], [[3r2o]], [[3r2r]], [[3r2s]] – BFR – ''Pseudomonas aeruginosa''<br />
**[[3is7]], [[3is8]], [[3ise]], [[3isf]], [[3r2h]], [[3r2k]], [[3r2l]], [[3r2m]], [[3r2o]], [[3r2r]], [[3r2s]] – BFR – ''Pseudomonas aeruginosa''<br />
**[[1bfr]], [[1bcf]], [[2htn]], [[2vxi]], [[3e1j]], [[3e1l]], [[3e1m]], [[3e1n]], [[3e1p]], [[3e1o]], [[3e1q]], [[2y3q]] – EcBFR <br />
**[[1bfr]], [[1bcf]], [[2htn]], [[2vxi]], [[3e1j]], [[3e1l]], [[3e1m]], [[3e1n]], [[3e1p]], [[3e1o]], [[3e1q]], [[2y3q]] – EcBFR <br />
-
**[[3e2c]], [[3ghq]] – EcBFR (mutant)<br />
+
**[[3e2c]], [[4cvr]], [[4cvt]] – EcBFR (mutant) + Zn<br />
-
**[[4am2]], [[4am4]], [[4am5]] – BFR – ''Blastochloris viridis''
+
**[[4cvp]], [[3ghq]] - EcBFR (mutant) + Fe<br />
 +
**[[4cvs]] – EcBFR (mutant) + Cd<br />
 +
**[[4am2]], [[4am4]], [[4am5]] – BFR + Fe – ''Blastochloris viridis''
*Thioferritin (TFR)
*Thioferritin (TFR)
Line 103: Line 118:
**[[3iq1]] – VcDps <br />
**[[3iq1]] – VcDps <br />
**[[3ge4]] – BmDps <br />
**[[3ge4]] – BmDps <br />
-
**[[2iy4]] – Dps – ''Listeria monocytogenes''<br />
+
**[[2iy4]] – Dps + Fe – ''Listeria monocytogenes''<br />
**[[2bkc]], [[2bk6]], [[2bjy]] – LiDps (mutant) <br />
**[[2bkc]], [[2bk6]], [[2bjy]] – LiDps (mutant) <br />
-
**[[2f7n]] – Dps – ''Deinococcus radiodurans''<br />
+
**[[2f7n]] – Dps + Co – ''Deinococcus radiodurans''<br />
-
**[[1tjo]], [[1tk6]], [[1tkp]], [[1tko]], [[1moj]] – Dps – ''Halobacterium salinarum''<br />
+
**[[4a25]] - Dps + Mn – ''Kinecoccus radiodurans''<br />
-
**[[1o9r]] – Dps – ''Agrobacterium tumefaciens''<br />
+
**[[1tjo]], [[1tk6]], [[1tkp]], [[1tko]], [[1moj]] – Dps + Fe – ''Halobacterium salinarum''<br />
-
**[[1dps]], [[1f30]], [[1f33]], [[1jre]] – EcDps <br />
+
**[[1o9r]] – Dps + Fe – ''Agrobacterium tumefaciens''<br />
 +
**[[1dps]], [[1f33]] – EcDps <br />
 +
**[[1f30]] – EcDps + Zn<br />
 +
**[[1jre]] – EcDps + Cd<br />
**[[1jts]], [[1l8h]], [[1l8i]] – EcDps (mutant)<br />
**[[1jts]], [[1l8h]], [[1l8i]] – EcDps (mutant)<br />
-
**[[2ux1]], [[2v15]], [[2xjm]], [[2xjn]], [[2xjo]], [[2xkq]] – Dps – ''Streptococcus suis''<br />
+
**[[2ux1]] – SsDps + Zn – ''Streptococcus suis''<br />
-
**[[2yw6]] – MsDps<br />
+
**[[2v15]] – SsDps + Te<br />
-
**[[3ak8]], [[3ak9]] – Dps – ''Salmonella enterica''<br />
+
**[[2xjm]] – SsDps + Co<br />
-
**[[1n1q]] – Dps – ''Brevibacillus brevis''<br />
+
**[[2xjn]] – SsDps + Cu<br />
-
**[[1vei]], [[1vel]], [[1veq]], [[2yw7]] – MsDps<br />
+
**[[2xjo]] – SsDps + Ni<br />
-
**[[4dyu]] – Dpo – ''Yersinia pestis''
+
**[[2xkq]] – SsDps + Mn<br />
 +
**[[2yw6]], [[2yw7]] – MsDps<br />
 +
**[[3ak8]], [[3ak9]] – Dps + Mg – ''Salmonella enterica''<br />
 +
**[[1n1q]] – Dps + Fe2O– ''Brevibacillus brevis''<br />
 +
**[[1vei]], [[1vel]], [[1veq]] – MsDps + Fe <br />
 +
**[[4dyu]] – Dpo + Zn – ''Yersinia pestis''
*MrgA
*MrgA

Revision as of 10:27, 2 April 2015

Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe Pyrococcus furiousus, 2jd7

Drag the structure with the mouse to rotate

Ferritin (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).

  • Bacterioferritin (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity.
  • Thioferritin (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.
  • Another iron storing protein is the DNA-binding Protein of Starved cells (Dps) - a ferritin-like diiron carboxylate.
  • MrgA – another iron storage protein - belongs to the Dps family.

3D Structures of Ferritin

Updated on 02-April-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, David Canner, Eran Hodis, Alexander Berchansky

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