Filamin

(Difference between revisions)

Revision as of 11:25, 6 January 2016

Crystal structure of Human Filamin A complex with phosphate, 3hop

Filamin A (FLNA) has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins.
Filamin B (FLNB) is a human cytoplasmic protein which functions similarly to FLNA and guides proper skeletal development.
Filamin C (FLNC) is functionally similar and contains 3 domains: the N-terminal ABD, the C-terminal dimerization domain (DD) and a membrane glycoprotein-binding domain.

For more details on filaminC see Group:MUZIC:FilaminC.

Updated on 06-January-2016

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 *  '''Filamin B (FLNB)''' is a human cytoplasmic protein which functions similarly to FLNA and guides proper skeletal development.<br />
 *  '''Filamin C (FLNC)''' is functionally similar and contains 3 domains: the N-terminal ABD, the C-terminal dimerization domain (DD) and a membrane glycoprotein-binding domain.<br />
-For more details on filaminC see [[Group:MUZIC:FilaminC]].  The images at the left and at the right correspond to one representative filamin structure, ''i.e.'' the crystal structure of human filamin A ([[3hop]]), it forms a <scene name='Filamin/Cv/2'>dimer</scene> <ref>PMID:19773341</ref>.  Two phosphate ions are rendered as space filling objects.
+For more details on filaminC see [[Group:MUZIC:FilaminC]].
 ==3D structures of filamin==